Objectives Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease characterized
by dry cough, fatigue, and progressive exertional dyspnea. Lung parenchyma and …

Fibrosis progression in the lung commonly results in impaired functional gas exchange,
respiratory failure, or even death. In addition to the aberrant activation and differentiation of …

Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …

Significance: The immune system plays a central role in orchestrating the tissue healing
process. Hence, controlling the immune system to promote tissue repair and regeneration is …

Macrophages play an important role in the innate and adaptive immune responses of organ
systems, including the lungs, to particles and pathogens. Cumulative results show that …

Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

The immune system plays a central role in tissue repair and regeneration. Indeed, the
immune response to tissue injury is crucial in determining the speed and the outcome of the …

The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …

Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Macrophages regulate tissue regeneration following injury. They can worsen tissue injury by
producing reactive oxygen species and other toxic mediators that disrupt cell metabolism …