Role of neuroglobin in the neuroprotective actions of estradiol and estrogenic compounds

GE Barreto, AJ McGovern, LM Garcia-Segura - Cells, 2021 - mdpi.com
Estradiol exerts neuroprotective actions that are mediated by the regulation of a variety of
signaling pathways and homeostatic molecules. Among these is neuroglobin, which is …

Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells

MA Semenova, RV Chertkova, MP Kirpichnikov… - Biomolecules, 2023 - mdpi.com
Neuroglobin, which is a heme protein from the globin family that is predominantly expressed
in nervous tissue, can promote a neuronal survivor. However, the molecular mechanisms …

Repurposing of tibolone in Alzheimer's disease

GE Barreto - Biomolecules, 2023 - mdpi.com
Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterised by the
accumulation of amyloid-beta and tau in the brain, leading to the progressive loss of memory …

Mitochondria dysfunction and inflammation in traumatic brain injury: androgens to the battlefront

AJ McGovern, GE Barreto - Androgens: Clinical Research and …, 2021 - liebertpub.com
The therapeutic response to traumatic brain injury (TBI) still lacks a strategy to treat its acute
and chronic phases. Given that TBI affects the lives of 1.5 million people a year, and the …

Proteomic and bioinformatic investigation of altered pathways in neuroglobin-deficient breast cancer cells

M Costanzo, M Fiocchetti, P Ascenzi, M Marino… - Molecules, 2021 - mdpi.com
Neuroglobin (NGB) is a myoglobin-like monomeric globin that is involved in several
processes, displaying a pivotal redox-dependent protective role in neuronal and extra …

Neuroglobin and mitochondria: The impact on neurodegenerative diseases

M Fiocchetti, P Cracco, E Montalesi… - Archives of Biochemistry …, 2021 - Elsevier
Dysfunctional mitochondria have severe consequences on cell functions including Reactive
Oxygen Specie (ROS) generation, alteration of mitochondrial signaling, Ca 2+ buffering, and …

New strategies for stroke therapy: nanoencapsulated neuroglobin

S Blanco, E Martínez-Lara, E Siles, MÁ Peinado - Pharmaceutics, 2022 - mdpi.com
Stroke is a global health and socio-economic problem. However, no efficient preventive
and/or palliative treatments have yet been found. Neuroglobin (Ngb) is an endogen …

Structural and (pseudo-) enzymatic properties of neuroglobin: Its possible role in neuroprotection

G De Simone, D Sbardella, F Oddone, A Pesce… - Cells, 2021 - mdpi.com
Neuroglobin (Ngb), the third member of the globin family, was discovered in human and
murine brains in 2000. This monomeric globin is structurally similar to myoglobin (Mb) and …

Evaluation of hsa-let-7d-5p, hsa-let-7g-5p and hsa-miR-15b-5p plasma levels in patients with Alzheimer's disease

E Poursaei, M Abolghasemi, S Bornehdeli… - Psychiatric …, 2022 - journals.lww.com
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder
MicroRNAs (miRNAs) may be promising diagnostic biomarkers for AD. Previous evidence …

[HTML][HTML] Identification of HMGCR, PPGARG and prohibitin as potential druggable targets of dihydrotestosterone for treatment against traumatic brain injury using …

AJ McGovern, J Gonzalez, D Ramírez… - International …, 2022 - Elsevier
Abstract Background Traumatic Brain Injury (TBI) has long-term devastating effects for which
there is no accurate and effective treatment for inflammation and chronic oxidative stress. As …