Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of
morbidity, mortality, and resource use worldwide. The goal of this Official American Thoracic …

Asthma remains a major health problem with significant morbidity, mortality and economic
costs. In asthma, airway remodelling, which refers to all the microscopic structural changes …

Background COPD is a heterogeneous disease characterized by airflow obstruction and
diagnosed by lung function. CT imaging is emerging as an important, noninvasive tool in …

Chronic obstructive pulmonary disease (COPD) involves a complex interaction of structural
and functional abnormalities. The two have long been studied in isolation. However …

Bronchial Thermoplasty (BT) is an endoscopic treatment for moderate-to-severe asthma
patients who are uncontrolled despite optimal medical therapy. Effectiveness of BT has been …

Background Lung cancer is the leading cause of cancer-related mortality. Radiology and
bronchoscopy techniques do not have the necessary resolution to evaluate lung lesions on …

Rationale: Lung carcinoma diagnosis on tissue biopsy can be challenging because of
insufficient tumor and lack of architectural information. Optical coherence tomography (OCT) …

Bronchial thermoplasty (BT) is a novel, nonpharmacological procedure for treatment of
severe asthma. Recently, the Asthma Intervention Research 2 clinical trial demonstrated …

BACKGROUND: Identifying different phenotypes of chronic obstructive pulmonary disease
(COPD) is important for both therapeutic options and clinical outcome of the disease …

Rationale: Cross-sectional studies of T-cell responses to self-antigens correlate with
baseline emphysema severity. Objectives: We investigated whether clinical and/or …