Preventing endometrial cancer risk in polycystic ovarian syndrome (PCOS) women: could metformin help?
MN Shafiee, G Khan, R Ariffin, J Abu, C Chapman… - Gynecologic …, 2014 - Elsevier
Current data indicate that there is a significant risk of endometrial cancer (EC) in women with
polycystic ovarian syndrome (PCOS), although further research needed to clarify the exact …
polycystic ovarian syndrome (PCOS), although further research needed to clarify the exact …
[HTML][HTML] Differential expression patterns of glycolytic enzymes and mitochondria-dependent apoptosis in PCOS patients with endometrial hyperplasia, an early …
T Wang, J Zhang, M Hu, Y Zhang, P Cui… - … Journal of Biological …, 2019 - ncbi.nlm.nih.gov
The underlying mechanisms of polycystic ovarian syndrome (PCOS)-induced endometrial
dysfunction are not fully understood, and although accumulating evidence shows that the …
dysfunction are not fully understood, and although accumulating evidence shows that the …
Up-regulation of genes involved in the insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link polycystic ovarian syndrome and endometrial …
MN Shafiee, C Seedhouse, N Mongan… - Molecular and cellular …, 2016 - Elsevier
Background Endometrial cancer (EC) is the most common gynaecological cancer amongst
women in the UK. Although previous studies have found that women with polycystic ovary …
women in the UK. Although previous studies have found that women with polycystic ovary …
Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer
P Huang, X Fan, H Yu, K Zhang, H Li, Y Wang… - Journal of Translational …, 2023 - Springer
Endometrial cancer (EC) is a common gynecological cancer that endangers women health.
Although substantial progresses of EC management have been achieved in recent years …
Although substantial progresses of EC management have been achieved in recent years …
Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma
Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive,
and antimetastatic effects of metformin in multiple cancer cell types, its cellular and …
and antimetastatic effects of metformin in multiple cancer cell types, its cellular and …
The complex triad of obesity, diabetes and race in Type I and II endometrial cancers: prevalence and prognostic significance
EM Ko, P Walter, L Clark, A Jackson, J Franasiak… - Gynecologic …, 2014 - Elsevier
Background We examined the distribution of obesity, diabetes, and race in Type I and Type
II endometrial cancers (EC) and their associations with clinical outcomes. Methods A multi …
II endometrial cancers (EC) and their associations with clinical outcomes. Methods A multi …
[HTML][HTML] The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: a prospective case control study
SJ Kitson, J Lindsay, VN Sivalingam, M Lunt… - Gynecologic …, 2018 - Elsevier
Background Cardiovascular disease is a major cause of death in endometrial cancer
survivors. The aim of this study was to determine whether women newly diagnosed with …
survivors. The aim of this study was to determine whether women newly diagnosed with …
[HTML][HTML] Combination of Diane-35 and metformin to treat early endometrial carcinoma in PCOS women with insulin resistance
Background: Young women with polycystic ovary syndrome (PCOS) have a high risk of
developing endometrial carcinoma. There is a need for the development of new medical …
developing endometrial carcinoma. There is a need for the development of new medical …
Insulin resistance and endometrial cancer: emerging role for microRNA
I Sidorkiewicz, M Jóźwik, M Niemira, A Krętowski - Cancers, 2020 - mdpi.com
Simple Summary Insulin resistance is one of the risk factors of endometrial cancer.
Hyperinsulinemia can trigger many physiological effects that drive carcinogenesis, which is …
Hyperinsulinemia can trigger many physiological effects that drive carcinogenesis, which is …
Prospective evaluation of the molecular effects of metformin on the endometrium in women with newly diagnosed endometrial cancer: A window of opportunity study
PT Soliman, Q Zhang, RR Broaddus, SN Westin… - Gynecologic …, 2016 - Elsevier
Objective Metformin reduces cancer incidence and improves overall survival in diabetic
patients. In preclinical studies, metformin decreases endometrial cancer (EC) cell growth by …
patients. In preclinical studies, metformin decreases endometrial cancer (EC) cell growth by …