[HTML][HTML] The emerging role of TET enzymes in the immune microenvironment at the maternal-fetal interface during decidualization and early pregnancy

M Jin, J Ji, X Chen, Y Zhou, D Wang, A Liu - Frontiers in Immunology, 2023 - frontiersin.org
A dysregulated immune microenvironment at the maternal-fetal interface in early pregnancy
may lead to early pregnancy loss, fetal growth restriction, and preeclampsia. However, major …

[HTML][HTML] TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation

Y Liu, T He, Z Li, Z Sun, S Wang, H Shen, L Hou, S Li… - Iscience, 2023 - cell.com
Ten-eleven translocation proteins (TETs) are dioxygenases that convert 5-methylcytosine
(5mC) to 5-hydroxymethylcytosine (5hmC), an important epigenetic mark that regulates …

[HTML][HTML] Alterations of the expression of TET2 and DNA 5-hmC predict poor prognosis in Myelodysplastic Neoplasms

AA Seethy, K Pethusamy, T Kushwaha, G Kumar… - BMC cancer, 2023 - Springer
Abstract Background Myelodysplastic Neoplasms (MDS) are clonal stem cell disorders
characterized by ineffective hematopoiesis and progression to acute myeloid leukemia …

[HTML][HTML] Can O-GIcNAc Transferase (OGT) Complex Be Used as a Target for the Treatment of Hematological Malignancies?

S Zhuang, Z Liu, J Wu, Y Yao, Z Li, Y Shen, B Yu… - Pharmaceuticals, 2024 - mdpi.com
The circulatory system is a closed conduit system throughout the body and consists of two
parts as follows: the cardiovascular system and the lymphatic system. Hematological …

[HTML][HTML] DNA methylation enzymes in the kidneys of male and female BTBR ob/ob mice

BM Veloso Pereira, M Charleaux de Ponte… - Frontiers in …, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is the leading cause of the end-stage renal disease. Recent
studies have shown that epigenetic modifications contribute to alterations in gene …

Virus-encoded glycosyltransferases hypermodify DNA with diverse glycans

JD Pyle, SR Lund, KH O'Toole, L Saleh - bioRxiv, 2023 - biorxiv.org
Enzymatic modification of DNA nucleobases can coordinate gene expression, protection
from nucleases, or mutagenesis. We recently discovered a new clade of phage-specific …

Exposition à l'alcool pendant la période préimplantatoire: conséquences sur l'épigénome et le développement embryonnaire

LM Legault - 2024 - papyrus.bib.umontreal.ca
Une exposition prénatale à l'alcool peut altérer le développement embryonnaire et causer le
Trouble du Spectre de l'Alcoolisation Fœtale (TSAF). Les mécanismes moléculaires menant …

[HTML][HTML] The Function of Ascorbic Acid through Occam's Razor: What We Know, What We Presume and What We Hope For

MC De Tullio - Ascorbic Acid-Biochemistry and Functions, 2023 - intechopen.com
After being identified as the anti-scurvy factor vitamin C, ascorbic acid (AsA) became the
subject of an astonishing amount of research. Many studies confirmed that AsA is essential …