ABSTRACT X‐linked hypophosphatemia (XLH) is characterized by increased activity of
circulating FGF23 resulting in renal phosphate wasting and abnormal bone mineralization …

Context Autosomal recessive hypophosphatemic rickets (ARHR) are rare, heritable renal
phosphate-wasting disorders that arise from overexpression of the bone-derived …

Background X-linked hypophosphataemia (XLH) is the most common heritable form of
rickets. Prevalence data varies across the literature between 1 in 20,000 and 1 in 200,000 …

X-linked hypophosphataemia (XLH) is a lifelong condition. Despite the mounting clinical
evidence highlighting the long-term multi-organ sequelae of chronic phosphate wasting and …

ABSTRACT X‐linked hypophosphatemia (XLH), caused by a loss‐of‐function mutation in
the phosphate regulating gene with homology to endopeptidase located on the X …

Following the serendipitous discovery of the ageing suppressor, αKlotho (αKl), several
decades ago, a growing body of evidence has defined a pivotal role for its various forms in …

The phenotypic spectrum of X-linked hypophosphatemia (XLH) ranges from isolated
hypophosphatemia to severe lower extremity bowing and/or craniosynostosis, usually …

Fibroblast growth factor 23 (FGF23) was identified at the turn of the century as the long-
sought circulating phosphatonin in human pathology. Since then, several clinical and …

X-linked hypophosphatemia (XLH) caused by PHEX mutations results in elevated serum
FGF23 levels, renal phosphate wasting and low 1, 25-dihydroxyvitamin D. The …

In recent years, much progress has been made in understanding the mechanisms of bone
growth and development over a lifespan, including the crosstalk between muscle and bone …