Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to
frank epithelial defect with or without stromal ulceration (melting) is associated with reduced …

Allodynia (pain due to a stimulus that does not usually provoke pain) and hyperalgesia
(increased pain from a stimulus that usually provokes pain) are prominent symptoms in …

Humans detect skin temperature changes that are perceived as warm or cool. Like humans,
mice report forepaw skin warming with perceptual thresholds of less than 1° C and do not …

Covering: 1989 to February 2011 Plant volatiles typically occur as a complex mixture of low-
molecular weight lipophilic compounds derived from different biosynthetic pathways, and …

The thermo‐transient receptor potentials (TRPs), a recently discovered family of ion
channels activated by temperature, are expressed in primary sensory nerve terminals where …

Basal tearing is crucial to maintaining ocular surface wetness. Corneal cold thermoreceptors
sense small oscillations in ambient temperature and change their discharge accordingly …

The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …

Somatosensory neurons detect environmental stimuli, converting external cues into neural
activity that is relayed first to second-order neurons in the spinal cord. The detection of cold …

The peripheral nociceptor is an important target of pain therapy because many pathological
conditions such as inflammation excite and sensitize peripheral nociceptors. Numerous ion …

Corneal nerves are instrumental to maintain cornea integrity through regulation of key
physiological functions such as tear secretion, blink reflex, and neuropeptide turnover …