Primary hepatocytes and their cultures are a simple but versatile, well-controlled, and
relatively easy to handle in vitro system that is well-accepted for investigating xenobiotic …

Gap junctions (GJ) and hemichannels (HC) formed from the protein subunits called
connexins are transmembrane conduits for the exchange of small molecules and ions …

Three-dimensional cell culture is emerging as a more relevant alternative to the traditional
two-dimensional format. Yet the ability to perform cytometry at the single cell level on intact …

In liver, like in other multicellular systems, the establishment of cellular contacts is a
prerequisite for normal functioning. In particular, well-defined cell junctions between …

Drug-induced organ toxicity/injury, especially in the liver, kidney, and gastrointestinal tract, is
a systematic disorder that causes oxidative stress formation and inflammation resulting in …

The present review provides the state of the art of the current knowledge concerning gap
junctional channels and their roles in liver functioning. In the first part, we summarize some …

We characterized the overall early effect of chronic ochratoxin A (OTA) treatment on rat liver,
analyzing different aspects related to:(i) fibrosis, by measuring collagen content and …

The aim of the study was to investigate the mechanisms of Ca2+ oscillation generation upon
activation of connexin-43 and regulation of the lipolysis/lipogenesis balance in white …

In the normal liver, cells interact closely through gap junctions. By providing a pathway for
the trafficking of low molecular mass molecules, these channels contribute to tissue …

Gap junctions, which mediate intercellular communication, are key players in digestive
homeostasis. They are also frequently involved in gastrointestinal and liver pathology. This …