Gap junctions are a specialized group of cell-to-cell junctions that mediate direct intercellular
communication between cells. They arise from the interaction of two hemichannels of …

Because of their critical role as goalkeepers of hepatic homeostasis, gap junctions are
frequent targets in liver disease. This concept has been demonstrated on many occasions in …

In normal liver, Connexin (Cx) 43 is not detected, but up-regulated in some liver cancers. We
herein investigated the role of Cx43 in hepatoma cell carcinogenesis. Cx43-silenced HuH7 …

The effects of histone deacetylase inhibitor Trichostatin A (TSA) on connexin (Cx)
expression and gap junctional intercellular communication (GJIC) were investigated in …

Connexins are goal keepers of tissue homeostasis, including in the liver. As a result, they
are frequently involved in disease. The current study was set up to investigate the effects of …

Gap junctions (GJs) play an important role in vascular function, stability, and homeostasis in
endothelial cells (ECs), and GJs are comprised of members of the connexin (Cx) family. GJs …

The establishment of an elaborate gap junctional intercellular communication network,
especially between hepatocytes, is important for normal liver development. In fact, the …

Although cell-cell interactions are known to significantly affect the kinetics of intracellular ice
formation (IIF) during tissue freezing, this effect is not well understood. Progress in …

Recently, epithelial-mesenchymal transition (EMT) has been reported to be an important
mechanism of drug resistance in numerous types of cancer cells, including hepatocellular …

Background Bi-potential hepatic progenitor cells can give rise to both hepatocytes and
cholangiocytes, which is the last phase and critical juncture in terms of sequentially hepatic …