Small-molecule drugs of colorectal cancer: Current status and future directions

Y Yang, P Liu, M Zhou, L Yin, M Wang, T Liu… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the world's
fourth most deadly cancer. CRC, as a genetic susceptible disease, faces significant …

Food matrix-flavonoid interactions and their effect on bioavailability

J Zhang, H Wang, C Ai, R Lu, L Chen… - Critical Reviews in …, 2023 - Taylor & Francis
Flavonoid compounds exhibit a wide range of health benefits as plant-derived dietary
components. Typically, co-consumed with the food matrix, they must be released from the …

Euphorbium total triterpenes improve Freund's complete adjuvant-induced arthritis through PI3K/AKT/Bax and NF-κB/NLRP3 signaling pathways

M Zhou, W Tan, J Liu, Z Gu, J Zhao - Journal of Ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance Euphorbium is the resinous secretion of Euphorbia
resinifera Berg. According to the record, Euphorbium was first used by Roman doctors to …

Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms

M Li, F Tian, J Guo, X Li, L Ma, M Jiang… - Frontiers in …, 2023 - frontiersin.org
Arthritis is a common degenerative disease of joints, which has become a public health
problem affecting human health, but its pathogenesis is complex and cannot be eradicated …

Naringin improves post-ischemic myocardial injury by activation of KATP channels

AM de Araujo, SVS de Cerqueira… - European Journal of …, 2023 - Elsevier
Naringin (NRG) is a flavonoid with recognized cardioprotective effects. Then, it was
investigated the cardioprotective mechanisms of NRG against ischemia-reperfusion (I/R) …

Regulatory mechanism and therapeutic potentials of naringin against inflammatory disorders

Y Peng, R Qu, S Xu, H Bi, D Guo - Heliyon, 2024 - cell.com
Naringin is a natural flavonoid with therapeutic properties found in citrus fruits and an active
natural product from herbal plants. Naringin has become a focus of attention in recent years …

Aerobic glycolysis in colon cancer is repressed by naringin via the HIF1A pathway

G Pan, P Zhang, A Chen, Y Deng, Z Zhang… - Journal of Zhejiang …, 2023 - Springer
Metabolic reprogramming is a common phenomenon in cancer, with aerobic glycolysis
being one of its important characteristics. Hypoxia-inducible factor-1α (HIF1A) is thought to …

Flavonoid intake in relation to colorectal cancer risk and blood bacterial DNA

MC Speciani, M Cintolo, M Marino, M Oren, F Fiori… - Nutrients, 2022 - mdpi.com
Flavonoids have been inversely associated to colorectal cancer (CRC) and are plausible
intermediaries for the relation among gut microbiome, intestinal permeability and CRC. We …

Evaluation and optimization of quality based on the physicochemical characteristics and metabolites changes of qingpi during storage

Y Cheng, C Wu, Z Liu, P Song, B Xu, Z Chao - Foods, 2023 - mdpi.com
Qingpi, the dried immature pericarp of Citrus reticulata Blanco, is a commonly used
medicinal food with some health-promoting benefits. In general, it is essential that Qingpi be …

Aspirin prevents colorectal cancer by regulating the abundance of Enterococcus cecorum and TIGIT+Treg cells

X Yang, Y Yan, F Wang, J Tian, Q Cao, M Liu, B Ma… - Scientific Reports, 2024 - nature.com
Although aspirin can reduce the incidence of colorectal cancer (CRC), there is still
uncertainty about its significance as a treatment for CRC, and the mechanism of aspirin in …