Traumatic brain injuries: pathophysiology and potential therapeutic targets

SY Ng, AYW Lee - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …

Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets

K Thapa, H Khan, TG Singh, A Kaur - Journal of Molecular Neuroscience, 2021 - Springer
Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary
injury mechanisms. Primary injury causes local brain damage, while secondary damage …

Cardiolipin, mitochondria, and neurological disease

M Falabella, HJ Vernon, MG Hanna… - Trends in Endocrinology …, 2021 - cell.com
Over the past decade, it has become clear that lipid homeostasis is central to cellular
metabolism. Lipids are particularly abundant in the central nervous system (CNS) where …

Animal models of traumatic brain injury

Y Xiong, A Mahmood, M Chopp - Nature Reviews Neuroscience, 2013 - nature.com
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity both in civilian life
and on the battlefield worldwide. Survivors of TBI frequently experience long-term disabling …

Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders

JM Saavedra - Clinical science, 2012 - portlandpress.com
The effects of brain AngII (angiotensin II) depend on AT1 receptor (AngII type 1 receptor)
stimulation and include regulation of cerebrovascular flow, autonomic and hormonal …

Traumatic brain injury increases cortical glutamate network activity by compromising GABAergic control

D Cantu, K Walker, L Andresen, A Taylor-Weiner… - Cerebral …, 2015 - academic.oup.com
Traumatic brain injury (TBI) is a major risk factor for developing pharmaco-resistant epilepsy.
Although disruptions in brain circuitry are associated with TBI, the precise mechanisms by …

Neurorehabilitation of traumatic brain injury (TBI): a clinical review

M Oberholzer, RM Müri - Medical Sciences, 2019 - mdpi.com
Traumatic brain injury (TBI) and its potential long-term consequences are of major concern
for public health. Neurorehabilitation of affected individuals has some specific characteristics …

[HTML][HTML] Amyloid-beta and tau protein beyond Alzheimer's disease

M Abyadeh, V Gupta, JA Paulo… - Neural Regeneration …, 2024 - journals.lww.com
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to
play key roles in Alzheimer's disease pathogenesis and are considered the main …

Incidence and risk factors of posttraumatic seizures following traumatic brain injury: a traumatic brain injury model systems study

AC Ritter, AK Wagner, A Fabio, MJ Pugh… - …, 2016 - Wiley Online Library
Objective Determine incidence of posttraumatic seizure (PTS) following traumatic brain
injury (TBI) among individuals with moderate‐to‐severe TBI requiring rehabilitation and …

A review of neuroprotection pharmacology and therapies in patients with acute traumatic brain injury

KW McConeghy, J Hatton, L Hughes, AM Cook - CNS drugs, 2012 - Springer
Traumatic brain injury (TBI) affects 1.6 million Americans annually. The injury severity
impacts the overall outcome and likelihood for survival. Current treatment of acute TBI …