Synopsis Atenolol is a selective β 1-adrenoceptor antagonist with a duration of activity of at
least 24 hours. The scope of therapeutic use of the drug has been expanded and become …

Purpose: To synthesize and analyze new information on the epidemiology, pathophysiology,
and management of hypertension in the elderly to guide physicians making treatment …

Objective To compare the effect of post‐operative analgesia using epidural versus
intravenous infusions on the incidence of delirium after bilateral knee replacement surgery …

Background: Little information has been published on the impact of antihypertensive
medications on quality of life in older persons. Particular concern has existed that lowering …

Objective: To evaluate treatment of mild hypertension using combinations of diet and low-
dose pharmacologic therapies. Design: Multicenter, randomized, placebo-controlled clinical …

To evaluate the comparative efficacy and cost-effectiveness of various antihypertensive
medications in persons aged 35 through 64 years with diastolic blood pressure of 95 mm Hg …

Vascular dementia is the second most common type of dementia in the elderly after the
dementia of Alzheimer's disease. Six forms of vascular dementia have been described: multi …

Catecholamines have an important endocrine and neuroendocrine role in mediating a
variety of autonomic functions. One consequence of normal aging, in particular in the …

• Fifty-five studies of cognitive side effects of β-blockers were reviewed. Many of the studies
were limited by small sample size, use of drugs out of the range of normal administration …

The association between antihypertensive medications and depression has been
recognised for over 40 years. More recently, our understanding of the role of …