The aim of this paper was to examine if there were clinical studies supporting a beneficial
effect of an even plasma concentration over 24 h for the most frequently prescribed β1 …

Atenolol and metoprolol are the two most widely used beta 1-adrenoceptor antagonists in
the treatment of essential hypertension. Differences in their physico-chemical properties …

The effect of treatment with the beta-blocker metoprolol on several indicants of task
performance was investigated. Twenty-five male hypertensives were treated for 2 weeks …

Antihypertensive medications are all associated with adverse reactions, and the elderly
patient may be particularly sensitive. In a large longitudinal follow up study in an aged …

Quality of life is becoming increasingly important in assessing the impact of therapy for
hypertension in elderly persons. Although the concept of quality of life is new and is in need …

Extensive research and clinical usage of metoprolol have shown the compound to be safe
and well tolerated if the contraindications are taken into consideration. However, as with …

What we are to describe is not a new problem. The story of Phineas Gage is a part of brain-
injury folklore and depicts the events following the passing of a tamping iron through the …

The lack of benefit and the potential negative side effects of β blockers are overstated,
especially in the elderly. This emphasis has led to recommendations by some investigators …

Selection of β-adrenergic blockers for formulary addition can be a difficult task, especially
with the increasing availability of new β-blockers, as well as the numerous differences in …

There is now a considerable body of evidence demonstrating the benefit of pharmacological
therapy in reducing cardiovascular risk in elderly hypertensive patients. With the high …