Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

Gliomas, and in particular glioblastoma multiforme, are aggressive brain tumors
characterized by a poor prognosis and high rates of recurrence. Current treatment strategies …

Survivin is a bifunctional protein that acts as a suppressor of apoptosis and plays a central
role in cell division. The protein is strongly expressed in the most common human …

Gene therapy represents a promising treatment alternative for patients with malignant
gliomas. Nevertheless, in the setting of these highly infiltrative tumors, transgene delivery …

Purpose: Diffuse intrinsic pontine glioma (DIPG) is among the deadliest of pediatric brain
tumors. Radiotherapy is the standard-of-care treatment for DIPG, but offers only transient …

Drug resistance remains a major clinical challenge for cancer treatment. One mechanism by
which tumor cells develop resistance to cytotoxic agents and radiation is related to …

Background: Survivin is a structurally unique member of the inhibitor of apoptosis protein
(IAP) family that acts as a suppressor of apoptosis and plays a central role in cell division …

Malignant brain cancer treatment is limited by a number of barriers, including the blood–
brain barrier, transport within the brain interstitium, difficulties in delivering therapeutics …

Despite decades of research and numerous clinical trials, the prognosis of patients
diagnosed with glioblastoma (GBM) remains dire with median observed survival at 8 …

The poor prognosis of patients with malignant gliomas necessitates the development of
novel therapies. Virotherapy, using genetically engineered adenovectors that selectively …