Beyond K48 and K63: non-canonical protein ubiquitination

M Tracz, W Bialek - Cellular & molecular biology letters, 2021 - Springer
Protein ubiquitination has become one of the most extensively studied post-translational
modifications. Originally discovered as a critical element in highly regulated proteolysis …

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

RING zinc finger proteins in plant abiotic stress tolerance

G Han, Z Qiao, Y Li, Z Yang, C Wang, Y Zhang… - Frontiers in plant …, 2022 - frontiersin.org
RING zinc finger proteins have a conserved RING domain, mainly function as E3 ubiquitin
ligases, and play important roles in plant growth, development, and the responses to abiotic …

Overexpression of tomato RING E3 ubiquitin ligase gene SlRING1 confers cadmium tolerance by attenuating cadmium accumulation and oxidative stress

GJ Ahammed, CX Li, X Li, A Liu, S Chen… - Physiologia …, 2021 - Wiley Online Library
Heavy metal pollution not only decreases crop yield and quality, but also affects human
health via the food chain. Ubiquitination‐dependent protein degradation is involved in plant …

Target protein degradation by protacs: a budding cancer treatment strategy

D Choudhary, A Kaur, P Singh, G Chaudhary… - Pharmacology & …, 2023 - Elsevier
Cancer is one of the most common causes of death. So, its lethal effect increases with time.
Near about hundreds of cancers are known in humans. Cancer treatment is done to cure or …

[HTML][HTML] miRNA transcriptome reveals key miRNAs and their targets contributing to the difference in Cd tolerance of two contrasting maize genotypes

L Teng, X Zhang, R Wang, K Lin, M Zeng… - Ecotoxicology and …, 2023 - Elsevier
Soil cadmium (Cd) contamination is a global environmental and food safety production
issue. microRNAs (miRNAs) are proven to be involved in plant growth and development …

[HTML][HTML] More than just cleaning: ubiquitin-mediated proteolysis in fungal pathogenesis

C Cao, C Xue - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Ubiquitin-proteasome mediated protein turnover is an important regulatory mechanism of
cellular function in eukaryotes. Extensive studies have linked the ubiquitin-proteasome …

The E3 ubiquitin ligase gene SlRING1 is essential for plant tolerance to cadmium stress in Solanum lycopersicum

ZY Qi, GJ Ahammed, CY Jiang, CX Li, J Zhou - Journal of Biotechnology, 2020 - Elsevier
The E3 ubiquitin ligases participate in the degradation of plant proteins and play a
regulatory role in stress response. However, the role of tomato E3 ubiquitin ligase genes in …

[HTML][HTML] South African wild fruits and vegetables under a changing climate: The implications on health and economy

SO Salami, OD Adegbaju, OA Idris, MO Jimoh… - South African Journal of …, 2022 - Elsevier
Overdependence on exotic plant species constitutes a major setback for the consumption of
wild fruits and vegetables among South Africans. The country is not spared from the adverse …

Advancement of targeted protein degradation strategies as therapeutics for undruggable disease targets

MP Kannan, S Sreeraman, CS Somala… - Future Medicinal …, 2023 - Future Science
Targeted protein degradation (TPD) aids in developing novel bifunctional small-molecule
degraders and eliminates proteins of interest. The TPD approach shows promising results in …