Immune mechanisms in pulmonary fibrosis
Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis, represents a chronic and
progressive disease with high mortality and limited therapeutic options. Excessive …
progressive disease with high mortality and limited therapeutic options. Excessive …
Pivotal roles of GM‐CSF in autoimmunity and inflammation
A Shiomi, T Usui - Mediators of inflammation, 2015 - Wiley Online Library
Granulocyte macrophage‐colony stimulating factor (GM‐CSF) is a hematopoietic growth
factor, which stimulates the proliferation of granulocytes and macrophages from bone …
factor, which stimulates the proliferation of granulocytes and macrophages from bone …
An official European Respiratory Society/American Thoracic Society research statement: interstitial pneumonia with autoimmune features
A Fischer, KM Antoniou, KK Brown… - European …, 2015 - Eur Respiratory Soc
Many patients with an idiopathic interstitial pneumonia (IIP) have clinical features that
suggest an underlying autoimmune process but do not meet established criteria for a …
suggest an underlying autoimmune process but do not meet established criteria for a …
Riociguat for idiopathic interstitial pneumonia-associated pulmonary hypertension (RISE-IIP): a randomised, placebo-controlled phase 2b study
Background Idiopathic interstitial pneumonias are often complicated by pulmonary
hypertension, increasing morbidity and mortality. There are no approved treatments for …
hypertension, increasing morbidity and mortality. There are no approved treatments for …
Effect of pirfenidone on mortality: pooled analyses and meta-analyses of clinical trials in idiopathic pulmonary fibrosis
Background In clinical trials of idiopathic pulmonary fibrosis, rates of all-cause mortality are
low. Thus prospective mortality trials are logistically very challenging, justifying the use of …
low. Thus prospective mortality trials are logistically very challenging, justifying the use of …
A risk score to detect subclinical rheumatoid arthritis–associated interstitial lung disease
PA Juge, B Granger, MP Debray… - Arthritis & …, 2022 - Wiley Online Library
Objective Patients at high risk of rheumatoid arthritis–associated interstitial lung disease (RA‐
ILD) would benefit from being identified before the onset of respiratory symptoms; this can …
ILD) would benefit from being identified before the onset of respiratory symptoms; this can …
Telomere length and genetic variant associations with interstitial lung disease progression and survival
CA Newton, JM Oldham, B Ley, V Anand… - European …, 2019 - Eur Respiratory Soc
Leukocyte telomere length (LTL), MUC5B rs35705950 and TOLLIP rs5743890 have been
associated with idiopathic pulmonary fibrosis (IPF). In this observational cohort study, we …
associated with idiopathic pulmonary fibrosis (IPF). In this observational cohort study, we …
Antifibrotic therapy for fibrotic lung disease beyond idiopathic pulmonary fibrosis
BF Collins, G Raghu - European Respiratory Review, 2019 - Eur Respiratory Soc
Two antifibrotic medications (nintedanib and pirfenidone) were recommended
(conditionally) for the treatment of patients with idiopathic pulmonary fibrosis (IPF) in the …
(conditionally) for the treatment of patients with idiopathic pulmonary fibrosis (IPF) in the …
2020 guide for the diagnosis and treatment of interstitial lung disease associated with connective tissue disease
Y Kondoh, S Makino, T Ogura, T Suda, H Tomioka… - Respiratory …, 2021 - Elsevier
The prognosis of patients with connective tissue disease (CTD) has improved significantly in
recent years, but interstitial lung disease (ILD) associated with connective tissue disease …
recent years, but interstitial lung disease (ILD) associated with connective tissue disease …
Serum KL-6 levels reflect the severity of interstitial lung disease associated with connective tissue disease
Background Biomarkers have been actively investigated to supplement functional and
imaging modalities to predict the severity, therapeutic responsiveness, and progression of …
imaging modalities to predict the severity, therapeutic responsiveness, and progression of …