G protein-coupled receptors (GPCRs) are the most intensively studied drug targets, mostly
due to their substantial involvement in human pathophysiology and their pharmacological …

Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction,
and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and …

Nanoplastics are being detected with increasing frequency in aquatic environments.
Although evidence suggests that nanoplastics can cause overt toxicity to biota across …

Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …

The plasma membrane of eukaryotic cells contains several types of lipids displaying high
biochemical variability in both their apolar moiety (eg, the acyl chain of glycerolipids) and …

Alzheimer's disease is a chronic illness with long preclinical and prodromal phases (20
years) and an average clinical duration of 8–10 years. The disease has an estimated …

G protein coupled receptors (GPCRs), also called 7TM receptors, form a huge superfamily of
membrane proteins that, upon activation by extracellular agonists, pass the signal to the cell …

Clinical studies indicate that Alzheimer's disease (AD) disproportionately affects women in
both disease prevalence and rate of symptom progression, but the mechanisms underlying …

Neurodegenerative diseases are a major public health problem worldwide with a wide
spectrum of symptoms and physiological effects. It has been long reported that the …

Compared to the better-known mu opioid receptor, delta opioid receptors have been
relatively understudied. However, the development of highly selective delta opioid agonists …