G‐protein‐coupled receptors (GPCR s) are the largest family of integral membrane
receptors with key roles in regulating signaling pathways targeted by therapeutics, but are …

Background Sex is increasingly recognized as a significant factor contributing to the
biological and clinical heterogeneity in AD. There is also growing evidence for the prominent …

The amyloid beta (Aβ) pathway is strongly implicated in neurodegenerative conditions such
as Alzheimer's disease and more recently, glaucoma. Here, we identify the α2 adrenergic …

Alzheimer's disease (AD) is a complex neurological disorder characterized by accumulation
of amyloid plaques and neurofibrillary tangles. Long term investigation of AD pathogenesis …

Post-translational modification of Tau, a microtubule-associated protein in the neuronal cell,
plays a major role in Alzheimer's disease. Tau is an axonal protein expressed in mature …

Tauopathies comprise a heterogeneous family of neurodegenerative diseases
characterized by pathological accumulation of hyperphosphorylated Tau protein …

Introduction Variability exists in the disease trajectories of Alzheimer's disease (AD) patients.
We performed a genome‐wide association study to examine rate of cognitive decline (ROD) …

Positron emission tomography (PET) is a molecular imaging modality that enables in vivo
exploration of metabolic processes and especially the pharmacology of neuroreceptors. G …

Alzheimer's disease (AD) is a progressive disorder affecting intellectual, behavioral and
functional abilities. It is associated with age and pathological alterations leading to the …

Cognitive and emotional impairment are a serious consequence of stress exposure and are
core features of neurological and psychiatric conditions that involve memory disorders …