Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

Bright-field light microscopy and related phase-sensitive techniques play an important role
in life sciences because they provide facile and label-free insights into biological specimens …

Eukaryotic cells use clathrin-mediated endocytosis to take up a large range of extracellular
cargo. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains …

Clathrin-mediated endocytosis enables selective uptake of molecules into cells in response
to changing cellular needs. It occurs through assembly of coat components around the …

Clathrin-mediated endocytosis (CME) is the main mechanism by which mammalian cells
control their cell surface proteome. Proper operation of the pivotal CME cargo adaptor AP2 …

Clathrin-mediated endocytosis (CME) requires energy input from actin polymerization in
mechanically challenging conditions. The roles of actin in CME are poorly understood due to …

Clathrin-mediated endocytosis (CME) begins with the nucleation of clathrin assembly on the
plasma membrane, followed by stabilization and growth/maturation of clathrin-coated pits …

The global prevalences of obesity and type 2 diabetes mellitus have reached epidemic
status, presenting a heavy burden on society. It is therefore essential to find novel …

Sculpting a flat patch of membrane into an endocytic vesicle requires curvature generation
on the cell surface, which is the primary function of the endocytosis machinery. Using super …