Effects of nanoparticle size and shape in clathrin-mediated endocytosis

W Xu, X Liu, X Liu - Journal of Applied Physics, 2022 - pubs.aip.org
Nanoparticles have been extensively adopted to deliver therapeutic drug molecules to cells
through clathrin-mediated endocytosis (CME). The size and shape of nanoparticles are …

Primary Human Breast Cancer‐Associated Endothelial Cells Favor Interactions with Nanomedicines

L Wang, V Sheth, K Liu, P Panja… - Advanced …, 2024 - Wiley Online Library
Cancer nanomedicines predominately rely on transport processes controlled by tumor‐
associated endothelial cells to deliver therapeutic and diagnostic payloads into solid tumors …

O-GlcNAc transferase modulates the cellular endocytosis machinery by controlling the formation of clathrin-coated pits

S Rahmani, H Ahmed, O Ibazebo… - Journal of Biological …, 2023 - ASBMB
Clathrin-mediated endocytosis (CME) controls the internalization and function of a wide
range of cell surface proteins. CME occurs by the assembly of clathrin and many other …

Spatiotemporal organization and correlation of tip-focused exocytosis and endocytosis in regulating pollen tube tip growth

X Weng, Y Shen, L Jiang, L Zhao, H Wang - Plant Science, 2023 - Elsevier
Pollen tube polar growth is a key cellular process during plant fertilization and is regulated
by tip-focused exocytosis and endocytosis. However, the spatiotemporal dynamics and …

ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals

N Pashkova, L Gakhar, L Yu, NJ Schnicker, AY Minard… - Elife, 2021 - elifesciences.org
Attachment of ubiquitin (Ub) to cell surface proteins serves as a signal for internalization via
clathrin-mediated endocytosis (CME). How ubiquitinated membrane proteins engage the …

Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis

PJ Cossar, D Cardoso, D Mathwin, CC Russell… - European Journal of …, 2023 - Elsevier
Abstract Wiskostatin (1-(3, 6-dibromo-9H-carbazol-9-yl)-3-(dimethylamino) propan-2-ol)(1) is
a carbazole-based compound reported as a specific and relatively potent inhibitor of the N …

Superresolution microscopy reveals partial preassembly and subsequent bending of the clathrin coat during endocytosis

M Mund, A Tschanz, YL Wu, F Frey, JL Mehl… - BioRxiv, 2021 - biorxiv.org
Eukaryotic cells use clathrin-mediated endocytosis to take up a large range of extracellular
cargos. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains …

[HTML][HTML] Antagonistic regulation controls clathrin-mediated endocytosis: AP2 adaptor facilitation vs restraint from clathrin light chains

L Redlingshöfer, FM Brodsky - Cells & Development, 2021 - Elsevier
Orchestration of a complex network of protein interactions drives clathrin-mediated
endocytosis (CME). A central role for the AP2 adaptor complex beyond cargo recognition …

Coarse-grained simulations suggest potential competing roles of phosphoinositides and amphipathic helix structures in membrane curvature sensing of the AP180 N …

A Belessiotis-Richards, AH Larsen… - The Journal of …, 2022 - ACS Publications
The generation and sensing of membrane curvature by proteins has become of increasing
interest to researchers with multiple mechanisms, from hydrophobic insertion to protein …

Imaging nanoscale axial dynamics at the basal plasma membrane

TJ Nawara, AL Mattheyses - The international journal of biochemistry & cell …, 2023 - Elsevier
Understanding of how energetically unfavorable plasma membrane shapes form, especially
in the context of dynamic processes in living cells or tissues like clathrin-mediated …