Chip-compatible wide-field 3D nanoscopy through tunable spatial frequency shift effect
Spatial frequency shift (SFS) microscopy with evanescent wave illumination shows intriguing
advantages, including large field of view (FOV), high speed, and good modularity. However …
advantages, including large field of view (FOV), high speed, and good modularity. However …
Multi‐modal adaptor‐clathrin contacts drive coated vesicle assembly
SM Smith, G Larocque, KM Wood, KL Morris… - The EMBO …, 2021 - embopress.org
Clathrin‐coated pits are formed by the recognition of membrane and cargo by the AP2
complex and the subsequent recruitment of clathrin triskelia. A role for AP2 in coated‐pit …
complex and the subsequent recruitment of clathrin triskelia. A role for AP2 in coated‐pit …
Regulation of acid-sensing ion channels by protein binding partners
MM Cullinan, RC Klipp, JR Bankston - Channels, 2021 - Taylor & Francis
Acid-sensing ion channels (ASICs) are a family of proton-gated cation channels that
contribute to a diverse array of functions including pain sensation, cell death during …
contribute to a diverse array of functions including pain sensation, cell death during …
Reconstituting membrane fission using a high content and throughput assay
U Swaminathan, TJ Pucadyil - Biochemical Society Transactions, 2024 - portlandpress.com
Protein-mediated membrane fission has been analyzed both in bulk and at the single event
resolution. Studies on membrane fission in vitro using tethers have provided fundamental …
resolution. Studies on membrane fission in vitro using tethers have provided fundamental …
Confocal interferometric scattering microscopy reveals 3D nanoscopic structure and dynamics in live cells
Bright-field light microscopy and related techniques continue to play a key role in life
sciences because they provide a facile and label-free insight into biological specimen …
sciences because they provide a facile and label-free insight into biological specimen …
[HTML][HTML] Fluidic shear stress alters clathrin dynamics and vesicle formation in endothelial cells
TJ Nawara, E Sztul, AL Mattheyses - bioRxiv, 2024 - ncbi.nlm.nih.gov
Endothelial cells (ECs) experience a variety of highly dynamic mechanical stresses. Among
others, cyclic stretch and increased plasma membrane tension inhibit clathrin-mediated …
others, cyclic stretch and increased plasma membrane tension inhibit clathrin-mediated …
Ubiquitin-driven protein condensation initiates clathrin-mediated endocytosis
Clathrin-mediated endocytosis is an essential cellular pathway that enables signaling and
recycling of transmembrane proteins and lipids. During endocytosis, dozens of cytosolic …
recycling of transmembrane proteins and lipids. During endocytosis, dozens of cytosolic …
Diversity, origin, and evolution of the ESCRT systems
KS Makarova, V Tobiasson, YI Wolf, Z Lu, Y Liu… - Mbio, 2024 - Am Soc Microbiol
Endosomal sorting complexes required for transport (ESCRT) play key roles in protein
sorting between membrane-bounded compartments of eukaryotic cells. Homologs of many …
sorting between membrane-bounded compartments of eukaryotic cells. Homologs of many …
Prodrugs of the Archetypal Dynamin Inhibitor Bis‐T‐22
LR Odell, MJ Robertson, KA Young… - …, 2022 - Wiley Online Library
The Bis‐T series of compounds comprise some of the most potent inhibitors of dynamin
GTPase activity yet reported, eg,(2E, 2′ E)‐N, N′‐(propane‐1, 3‐diyl) bis (2‐cyano‐3‐(3 …
GTPase activity yet reported, eg,(2E, 2′ E)‐N, N′‐(propane‐1, 3‐diyl) bis (2‐cyano‐3‐(3 …
[HTML][HTML] Integrating protein copy numbers with interaction networks to quantify stoichiometry in clathrin-mediated endocytosis
D Duan, M Hanson, DO Holland, ME Johnson - Scientific Reports, 2022 - nature.com
Proteins that drive processes like clathrin-mediated endocytosis (CME) are expressed at
copy numbers within a cell and across cell types varying from hundreds (eg auxilin) to …
copy numbers within a cell and across cell types varying from hundreds (eg auxilin) to …