Pharmacokinetics and pharmacodynamics of high doses of inhaled dry powder drugs
MK Hatipoglu, AJ Hickey, L Garcia-Contreras - International journal of …, 2018 - Elsevier
For many years, administration of drugs by inhalation has been the mainstay treatment for
obstructive respiratory disorders such as asthma and chronic obstructive pulmonary …
obstructive respiratory disorders such as asthma and chronic obstructive pulmonary …
Pharmacokinetic/pharmacodynamic approaches to drug delivery design for inhalation drugs
MG Matera, L Calzetta, J Ora, P Rogliani… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Inhaled drugs are important in the treatment of many lung pathologies, but to be
therapeutically effective they must reach unbound concentrations at their effect site in the …
therapeutically effective they must reach unbound concentrations at their effect site in the …
Excipient-free isoniazid aerosol administration in mice: Evaporation-nucleation particle generation, pulmonary delivery and body distribution
SV Valiulin, AA Onischuk, AM Baklanov… - International Journal of …, 2019 - Elsevier
Excipient-free isoniazid aerosol formation and pulmonary delivery in mice are studied. An
evaporation-nucleation route is used for the generation of isoniazid aerosol. Particle …
evaporation-nucleation route is used for the generation of isoniazid aerosol. Particle …
[HTML][HTML] The Pharmacokinetics of CPZEN-45, a Novel Anti-Tuberculosis Drug, in Guinea Pigs
CPZEN-45 is a novel compound with activity against drug-susceptible and drug-resistant
tuberculosis (TB). The present study was undertaken to determine the best dose and dosing …
tuberculosis (TB). The present study was undertaken to determine the best dose and dosing …
[HTML][HTML] Studies of the specific activity of aerosolized isoniazid against tuberculosis in a mouse model
SV Valiulin, AA Onischuk, AM Baklanov, SN Dubtsov… - Antibiotics, 2022 - mdpi.com
The aerosol inhalation delivery of isoniazid in mice was investigated, and the specific activity
of the aerosol form of isoniazid was studied with the mouse model of tuberculosis infection …
of the aerosol form of isoniazid was studied with the mouse model of tuberculosis infection …
Bioavailability of inhaled compounds
L Garcia-Contreras - Inhalation aerosols, 2019 - taylorfrancis.com
The US Food and Drug Administration (USFDA) defines bioavailability as “[t] he rate and
extent to which the active ingredient or active moiety is absorbed from a drug product and …
extent to which the active ingredient or active moiety is absorbed from a drug product and …