Cancer vaccines, which directly pulsed in vivo dendritic cells (DCs) with specific antigens
and immunostimulatory adjuvants, showed great potential for cancer immunoprevention …

CpG oligodeoxynucleotides (ODN) are short single-stranded synthetic DNA molecules that
activate the immune system and have been found to be effective for preventing and treating …

Background: Recent studies have demonstrated that bacterially derived immunostimulatory
sequences (ISSs) of DNA can activate the mammalian innate immune system and promote …

Cancer immunotherapy is a treatment that utilizes the host immune system to fight against
cancer. Inducing a cancer antigen-specific adaptive immune response is key in cancer …

In recent years, the position of the innate immune system in regulating nearly all immune
responses has become well established. A central tenet in understanding the function of the …

While the importance of immunological adjuvants for optimal induction of antibody and T-cell
responses against tumor antigens is clear, the relevant potency of different adjuvants is not …

Previous studies have shown that the action of bacterial or synthetic oligodeoxynucleotide
(oligo-DNA) on mouse NK cells to produce IFN-γ is mediated mostly by monocytes …

The field of DNA nanotechnology has progressed rapidly in recent years and hence a large
variety of 1D-, 2D-and 3D DNA nanostructures with various sizes, geometries and shapes is …

Following injury, bone has the ability to regenerate itself to a form and function nearly
indistinguishable from the pre-injury state. However, if the injury is beyond a critical limit …

Unmethylated CpG dinucleotide motifs in bacterial DNA, as well as oligodeoxynucleotides
(ODN) containing these motifs, are potent stimuli for many host immunological responses …