Inverted terminal repeats (ITRs) are the only wild-type components retained in the genome
of adeno-associated virus (AAV) vectors. To determine whether ITR modification is a viable …

The application of natural carbohydrate polysaccharides for antigen delivery and its
adjuvanation potential has garnered interest in the scientific community in the recent years …

Cytosine–phosphorothioate–guanine oligodeoxynucleotides (CpG ODN) is a recent class of
immunostimulatory adjuvants that includes unmethylated CpG dinucleotide sequences …

A specific set of immune functions is switched on in response to DNA containing
unmethylated CpG dinucleotides in particular base contexts ('CpG motifs'). Plasmids, viral …

Nanoparticles have emerged as the platform of choice to improve the efficacy and safety of
subunit vaccines. A major challenge underlying the use of nanomaterials in vaccines lies in …

Innate immunity provides the first line of defense against invading pathogens and is
essential for survival in the absence of adaptive immune responses. Innate immune …

Establishing the effective use of 'naked'nucleic acids as vaccines would undoubtedly be one
of the most important advances in the history of vaccinology. While nucleic acids show much …

Immune stimulation has been widely recognized as an undesirable side effect of certain
antisense oligodeoxynucleotides (ODN) which can interfere with their therapeutic …

US7534772B2 - Methods for enhancing antibody-induced cell lysis and treating cancer -
Google Patents US7534772B2 - Methods for enhancing antibody-induced cell lysis and …

Resistance to murine leishmaniasis correlates with development of a CD4+ T helper 1 (Th1)-
predominant immune response. To determine whether immunostimulatory CpG-containing …