[HTML][HTML] Nasal epithelial barrier integrity and tight junctions disruption in allergic rhinitis: overview and pathogenic insights

SM Nur Husna, HTT Tan, N Md Shukri… - Frontiers in …, 2021 - frontiersin.org
Allergic rhinitis (AR) is a common disorder affecting up to 40% of the population worldwide
and it usually persists throughout life. Nasal epithelial barrier constitutes the first line of …

Nanomaterials responsive to endogenous biomarkers for cardiovascular disease theranostics

C Wei, Z Jiang, C Li, P Li, Q Fu - Advanced Functional Materials, 2023 - Wiley Online Library
Cardiovascular disease (CVD) is the number one cause of death worldwide, which propels
the development of advanced technologies for CVD diagnosis and treatment. Biomarker …

Mechanisms and strategies to enhance penetration during intravesical drug therapy for bladder cancer

P Zhang, G Wu, D Zhang, WF Lai - Journal of Controlled Release, 2023 - Elsevier
Bladder cancer (BCa) is one of the most prevalent cancers worldwide. The effectiveness of
intravesical therapy for bladder cancer, however, is limited due to the short dwell time and …

Recent advances in the metal/organic hybrid nanomaterials for cancer theranostics

Z Ye, Y Bao, Z Chen, H Ye, Z Feng, Y Li, Y Zeng… - Coordination Chemistry …, 2024 - Elsevier
Cancer is an extremely significant disease that profoundly impacts human survival and
quality of life. Researchers have been searching for effective therapies, among which …

[HTML][HTML] How the innate immune DNA sensing cGAS–STING pathway is involved in autophagy

W Zheng, N Xia, J Zhang, N Chen, F Meurens… - International Journal of …, 2021 - mdpi.com
The cGAS–STING pathway is a key component of the innate immune system and exerts
crucial roles in the detection of cytosolic DNA and invading pathogens. Accumulating …

[HTML][HTML] Connexin channels modulation in pathophysiology and treatment of immune and inflammatory disorders

A Tittarelli - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2021 - Elsevier
Connexin-mediated intercellular communication mechanisms include bidirectional cell-to-
cell coupling by gap junctions and release/influx of molecules by hemichannels. These …

[HTML][HTML] Connexin 43 and sonic hedgehog pathway interplay in glioblastoma cell proliferation and migration

F Torrisi, C Alberghina, D Lo Furno, A Zappalà… - Biology, 2021 - mdpi.com
Simple Summary Glioblastoma is the product of accumulated genetic and epigenetic
alteration where tumor cells support each other through cellular communication …

cGAS-STING at the crossroads in cancer therapy

R Wang, A Hussain, Q Guo, M Ma - Critical Reviews in Oncology …, 2023 - Elsevier
DNA is highly immunogenic, both exogenous and endogenous DNA can activate the
pathogen-associated molecular pattern (PAMP) and danger-associated molecular pattern …

Connexin-containing vesicles for drug delivery

MS Hanafy, Z Cui - The AAPS Journal, 2024 - Springer
Connexin is a transmembrane protein present on the cell membrane of most cell types.
Connexins assemble into a hexameric hemichannel known as connexon that pairs with …

Spotlight on liver macrophages for halting liver disease progression and injury

A Khurana, U Navik, P Allawadhi, P Yadav… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Over the past two decades, understanding of hepatic macrophage biology has
provided astounding details of their role in the progression and regression of liver diseases …