The lymphatic system (LS) is composed of lymphoid organs and a network of vessels that
transport interstitial fluid, antigens, lipids, cholesterol, immune cells, and other materials in …

Lymph node metastasis is a crucial prognostic parameter in many different types of cancers
and a gateway for further dissemination to distant organs. Prior to metastatic dissemination …

Fibroblastic reticular cells (FRCs) are a crucial part of the stromal cell infrastructure of
secondary lymphoid organs (SLOs). Lymphoid organ fibroblasts form specialized niches for …

Dendritic cells (DCs) are crucial for the appropriate initiation of adaptive immune responses.
During inflammation, DCs capture antigens, mature, and migrate to lymphoid tissues to …

Fibroblastic reticular cells (FRCs) are specialized fibroblasts of secondary lymphoid organs
that provide the structural foundation of the tissue. Moreover, FRCs guide immune cells to …

Lymph node (LN) fibroblastic reticular cells (FRCs) define LN niches and regulate
lymphocyte homeostasis through producing diverse extracellular matrix (ECM) components …

Historically, research into the lymphatic system has been overlooked due to both a lack of
knowledge and limited recognition of its importance. In the last decade however, lymphatic …

We previously developed a mechanism-based pharmacokinetic (MBPK) model to
characterize the PK of a lymphocyte-targeted, long-acting 3 HIV drug-combination …

In obesity, increased dietary lipids are taken up and transported by the lymphatic systems
into the circulatory system. Increased fat accumulation results in impairments in the lymph …

With growing molecular evidence for correlations between spatial arrangement of blood
vasculature and fundamental immunological functions, carried out in distinct compartments …