Epilepsy is a common and serious neurologic disease with a strong genetic component.
Genetic studies have identified an increasing collection of disease-causing genes. The …

Astrocytes outnumber neurons in the human brain, and they play a key role in numerous
functions within the central nervous system (CNS), including glutamate, ion (ie, Ca2+, K+) …

Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …

Bile acids (BA) are amphipathic steroid acids synthesized from cholesterol in the liver. They
act as detergents to expedite the digestion and absorption of dietary lipids and lipophilic …

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and the
leading monogenic cause of autism. The condition stems from loss of fragile X mental …

Within the potassium ion channel family, calcium activated potassium (KCa) channels are
unique in their ability to couple intracellular Ca2+ signals to membrane potential variations …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

KCNMA1 encodes the pore-forming α subunit of the “Big K+”(BK) large conductance calcium
and voltage-activated K+ channel. BK channels are widely distributed across tissues …

Large-conductance Ca2+-activated K+ channels facilitate the efflux of K+ ions from a variety
of cells and tissues following channel activation. It is now recognized that BK channels …

Animals synchronize to the environmental day-night cycle by means of an internal circadian
clock in the brain. In mammals, this timekeeping mechanism is housed in the …