After more than a century from its discovery, valproic acid (VPA) still represents one of the
most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a …

Valproic acid (VPA) is both an anti-convulsant and a mood stabilizer. Clinical studies over
the past 40years have shown that exposure to VPA in utero is associated with birth defects …

Acute seizures after a severe brain insult can often lead to epilepsy and cognitive
impairment. Aberrant hippocampal neurogenesis follows the insult but the role of adult …

Prevention of epileptogenesis after brain trauma is an unmet medical challenge. Recent
molecular profiling studies have provided an insight into molecular changes that contribute …

There is growing evidence that ketone bodies, which are derived from fatty acid oxidation
and usually produced in fasting state or on high-fat diets have broad neuroprotective effects …

Changes in gene expression in the brain may underlie cognitive deficits inherent to normal
aging and neurodegenerative disease. However, the mechanisms underlying pathological …

Valproic acid (VPA) is an approved drug for managing epileptic seizures, bipolar disorders,
and migraine. VPA has been shown to elevate the level of gamma-aminobutyric acid …

Parkinson's disease (PD) is the most common movement disorder affecting more than 4
million people worldwide. The primary motor symptoms of the disease are due to …

Background Alzheimer's disease (AD) is a devastating neurodegenerative ailment having
pathological hallmarks of plaques due to amyloid β (Aβ) peptides and neurofibrillary tangles …

Schizophrenia is a neurodevelopmental disorder with genetic predisposition, and stress has
long been linked to its etiology. While stress affects all stages of the illness, increasing …