[HTML][HTML] Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications

M Guo, X Sun, J Chen, T Cai - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Pharmaceutical cocrystals are multicomponent systems in which at least one component is
an active pharmaceutical ingredient and the others are pharmaceutically acceptable …

Cocrystal engineering of pharmaceutical solids: Therapeutic potential and challenges

SN Wong, YCS Chen, B Xuan, CC Sun, SF Chow - CrystEngComm, 2021 - pubs.rsc.org
Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …

Diffusion and Flux Improvement of Drugs through Complexation

MKC Mannava, A Garai, AK Nangia - Molecular Pharmaceutics, 2023 - ACS Publications
Improving the solubility and permeability of drugs via cocrystallization is an important theme
in crystal engineering with practical applications for the discovery and development of high …

[HTML][HTML] Amino acids as the potential co-former for co-crystal development: a review

I Nugrahani, MA Jessica - Molecules, 2021 - mdpi.com
Co-crystals are one of the most popular ways to modify the physicochemical properties of
active pharmaceutical ingredients (API) without changing pharmacological activity through …

An outlook on permeability escalation through cocrystallization for developing pharmaceuticals with improved biopharmaceutical properties

N Pandey, A Ghosh - Journal of Drug Delivery Science and Technology, 2022 - Elsevier
Permeability of any pharmaceutical is critically significant for its biopharmaceutical profile,
therapeutic activities, and deciding its dosing regimen. Approximately 35% of the marketed …

Directed Self-Assembly with Gallic Acid Provides First Phenolic Acid Cocrystals for the Antiviral Drug Acyclovir toward Increasing Pharmaceutical Features and …

FZ Bu, YM Yu, M Zhang, CW Yan, ZY Wu… - Crystal Growth & …, 2023 - ACS Publications
To achieve new breakthroughs in the development of synergistic antiviral medication
cocrystals of acyclovir (AYL) with phenolic acids, a cocrystallization-driven strategy for …

Molecular complexes of drug combinations: a review of cocrystals, salts, coamorphous systems and amorphous solid dispersions

J Li, X Wang, D Yu, Y Zhoujin, K Wang - International Journal of …, 2023 - Elsevier
As the advancements in the medical technology and healthcare develop through the years,
combinational therapy has evolved to be an important treatment modality in many disease …

Directional Self-Assembly of Ofloxacin and Syringic Acid: The First Salt Cocrystal of Ofloxacin with Phenolic Acid Displays Superior In Vitro/Vivo Biopharmaceutical …

SS Meng, YM Yu, FZ Bu, CW Yan, ZY Wu… - Crystal Growth & …, 2022 - ACS Publications
A cocrystallization tactic of double optimization and synergistic enhancement efficacy has
been proposed, aiming at maximizing the benefits of phenolic acid nutriment syringic acid …

Two cocrystal polymorphs of palmatine chloride with racemic hesperetin

Y Zhang, Y Li, L Liu, Q Guo, R Sa… - Crystal Growth & …, 2021 - ACS Publications
Two polymorphic cocrystals of palmatine chloride with racemic hesperetin (Form I and Form
II) have been prepared and investigated systematically. Crystal structure analysis reveals …

Novel formulations of the antiviral drug favipiravir: Improving permeability and tabletability

X Wang, L Wang, C Yao, G Xie, S Song… - Crystal Growth & …, 2021 - ACS Publications
Recently, favipiravir, as a broad-spectrum antiviral drug, has gain more attention because it
might be a candidate to remedy the coronavirus disease 2019 (COVID-19). To improve its …