Acute myocardial infarction (MI) inflicts massive injury to the coronary microcirculation
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …

Endothelial cells (ECs) constitute the innermost layer in all blood vessels to maintain the
structural integrity and microcirculation function for coronary microvasculature. Impaired …

Heart disease is a major cause of death worldwide with increasing prevalence, which urges
the development of new therapeutic strategies. Over the last few decades, numerous small …

Cardioprotection aims at infarct size reduction and improvement of clinical outcome from
myocardial infarction. The translation of cardioprotection from preclinical and promising …

Acute myocardial infarction (AMI) and the heart failure (HF) which may follow are among the
leading causes of death and disability worldwide. As such, new therapeutic interventions are …

The roles and the underlying mechanisms of M1-type macrophages in angiogenesis and
postmyocardial infarction (MI) cardiac repair have remained unclear. In this study, we …

Primary percutaneous coronary intervention is nowadays the preferred reperfusion strategy
for patients with acute ST-segment–elevation myocardial infarction, aiming at restoring …

Early mechanical reperfusion of the epicardial coronary artery by primary percutaneous
coronary intervention (PCI) is the guideline-recommended treatment for ST-elevation …

Current evidence indicates that coronary microcirculation is a key target for protecting
against cardiac ischemia–reperfusion (I/R) injury. Mitochondrial calcium uniporter (MCU) …

Abstract Sphingosine-1-phosphate (S1P) is a signaling lipid, synthetized by sphingosine
kinases (SPHK1 and SPHK2), that affects cardiovascular function in various ways. S1P …