The granule exocytosis pathway of cytotoxic lymphocytes is crucial for immune surveillance
and homeostasis. The trafficking of granule components, including the membrane-disruptive …

The C2 domain is a Ca2+‐binding motif of approximately 130 residues in length originally
identified in the Ca2+‐dependent isoforms of protein kinase C. Single and multiple copies of …

The P2Z receptor is responsible for adenosine triphosphate (ATP)-dependent lysis of
macrophages through the formation of membrane pores permeable to large molecules …

Human CD8+ memory-and effector-type T cells are poorly defined. We show here that, next
to a naive compartment, two discrete primed subpopulations can be found within the …

Immune surveillance by cytotoxic lymphocytes against cancer has been postulated for
decades, but direct evidence for the role of cytotoxic lymphocytes in protecting against …

The cytotoxic potential of CD8+ T cells and NK cells plays a crucial role in the immune
response to pathogens. Although in vitro studies have reported that CD4+ T cells are also …

Microsatellite instability (MSI) characterizes colorectal carcinomas (CRCs) in hereditary
nonpolyposis colorectal cancer (HNPCC) syndrome and a proportion of sporadic CRCs …

One of the functions of the immune system is to recognize and destroy abnormal or infected
cells to maintain homeostasis. This is accomplished by cytotoxic lymphocytes. Cytotoxicity is …

The use of peptide–human histocompatibility leukocyte antigen (HLA) class I tetrameric
complexes to identify antigen-specific CD8+ T cells has provided a major development in …

Background Acute rejection is a serious and frequent complication of renal transplantation,
and its diagnosis is contingent on the invasive procedure of allograft biopsy. A noninvasive …