Granzyme B (GzmB) is used by cytotoxic lymphocytes as a molecular weapon for the
defense against virus‐infected and malignantly transformed host cells. It belongs to a family …

Lymphocytes are equipped to eradicate noxious agents (microbes, cancer cells, and grafts)
that disturb the body's equilibrium, but when their cellular activity is excessive, the results are …

In response to viral infection, unprimed naive CD8+, major histocompatibility complex class I—
restricted, virus-specific T cells clonally expand and differentiate into memory-and effector …

Introduction Lichenoid drug eruption (LDE) shares similar features with lichen planus (LP),
that could reflect the same pathogenesis. In LP, an autoimmune attack is accepted and …

Granulysin has been identified as an effector molecule co-localized with perforin in the
cytotoxic granules of cytotoxic T lymphocytes and natural killer (NK) cells, and has been …

Host defense against mycobacterial infection requires the participation of monocytes and T
cells. Both CD4+ and CD8+ T cells have been shown to be important in resistance to …

Bispecific monoclonal antibodies (bsAbs) are a promising immunotherapeutic option for
treatment of cancer, especially in situations of minimal residual disease. The combination of …

Medicinal mushrooms have been used for centuries in Asian countries owing to their
beneficial effects on health and longevity. Previous studies have reported that a single …

Perforin: more than just an effector molecule: Immunology Today Skip to Main Content
Advertisement Trends in Immunology This journal offers authors two options (open access or …

Experimental autoimmune neuritis (EAN) is a T-cell-mediated autoimmune disease of the
peripheral nervous system (PNS) that can be actively induced in Lewis rats by immunization …