Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …

Kidney disease (KD) is a life-threatening disease characterized by high morbidity and
mortality in clinical settings, which can be caused by many reasons, and the incidence …

Sulfonamide derivatives exhibit a wide biological activity and can function as potential
medical molecules in the development of a drug. Studies have reported that the compounds …

Background Diabetic nephropathy (DN) is a severe complication of diabetes mellitus and a
common cause of end-stage renal disease (ESRD). Mesenchymal stem cells (MSCs) …

Exosomes are membrane-enclosed vesicles secreted by cells, containing a variety of
biologically active ingredients including proteins, nucleic acids and lipids. In this study, we …

The nephrotoxicity of cisplatin (CIS) is a significant complication that challenges its clinical
applicability. The epithelial to mesenchymal transition (EMT) may be included in the …

Despite its clinical value, cisplatin (CISP) is complicated by marked hepatotoxicity via
inducing oxidative stress, inflammatory, and apoptotic pathways. This study aims to explore …

Tumor necrosis factor (TNF)-α-induced gene/protein (TSG)-6 regulates the
immunomodulatory properties of mesenchymal stem cells (MSCs), but its ability to protect …

A broad spectrum of lethal kidney diseases involves the irreversible destruction of the
tubular structures, leading to renal function loss. Following injury, a spectrum of tissue …

Novel Ru (II) complexes of Shiff base derivatives of 3-[(4-amino-5-thioxo-1, 2, 4-triazole-3-yl)
methyl]-2 (3H)-benzoxazolone were synthesized. The ligands (1a-e) were confirmed by IR, 1 …