Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases

Y Huang, RW Mahley - Neurobiology of disease, 2014 - Elsevier
Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism,
neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3 …

[HTML][HTML] Gamma-aminobutyric acid and probiotics: Multiple health benefits and their future in the global functional food and nutraceuticals market

L Diez-Gutiérrez, L San Vicente, LJR Barrón… - Journal of Functional …, 2020 - Elsevier
Probiotics have attracted growing interest in recent decades due to their multiple health
benefits. The synergistic relationship between probiotics and prebiotics can enhance the …

Gamma-aminobutyric acid as a bioactive compound in foods: a review

M Diana, J Quílez, M Rafecas - Journal of functional foods, 2014 - Elsevier
Gamma-aminobutyric acid (GABA) is a non-protein amino acid, considered a potent
bioactive compound. GABA has been widely studied because of its numerous physiological …

[HTML][HTML] GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease

J Jiménez-Balado, TS Eich - Seminars in cell & developmental biology, 2021 - Elsevier
In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …

[HTML][HTML] Human astrocytes in the diseased brain

E Dossi, F Vasile, N Rouach - Brain research bulletin, 2018 - Elsevier
Astrocytes are key active elements of the brain that contribute to information processing.
They not only provide neurons with metabolic and structural support, but also regulate …

Dementia in Down's syndrome

C Ballard, W Mobley, J Hardy, G Williams… - The Lancet …, 2016 - thelancet.com
Down's syndrome is the most common genetic cause of learning difficulties, and individuals
with this condition represent the largest group of people with dementia under the age of 50 …

Towards a better understanding of GABAergic remodeling in Alzheimer's disease

K Govindpani, B Calvo-Flores Guzmán… - International journal of …, 2017 - mdpi.com
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain.
In the past, there has been a major research drive focused on the dysfunction of the …

Lactic acid bacterial cell factories for gamma-aminobutyric acid

H Li, Y Cao - Amino acids, 2010 - Springer
Gamma-aminobutyric acid is a non-protein amino acid that is widely present in organisms.
Several important physiological functions of gamma-aminobutyric acid have been …

Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function

MJR Howes, PJ Houghton - Pharmacology Biochemistry and Behavior, 2003 - Elsevier
In traditional practices of Ayurvedic and Chinese medicine, numerous plants have been
used to treat cognitive disorders, including neurodegenerative diseases such as Alzheimer's …

Current advances in naturally occurring caffeoylquinic acids: Structure, bioactivity, and synthesis

W Liu, J Li, X Zhang, Y Zu, Y Yang, W Liu… - Journal of agricultural …, 2020 - ACS Publications
Caffeoylquinic acids (CQAs) are a broad class of secondary metabolites that have been
found in edible and medicinal plants from various families. It has been 100 years since the …