The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …

Mitochondria are key intracellular organelles involved not only in the metabolic state of the
cell, but also in several cellular functions, such as proliferation, Calcium signaling, and lipid …

Apoptosis is an intrinsic biochemical, cellular process that regulates cell death and is crucial
for cell survival, cellular homeostasis, and maintaining the optimum functional status …

WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

Cholesterol is a critical component of membrane bilayers where it plays key structural and
functional roles by regulating the activity of diverse signaling platforms and pathways …

Methylene blue (MB) is a well-established drug with a long history of use, owing to its
diverse range of use and its minimal side effect profile. MB has been used classically for the …

Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …

Glioblastoma (GB) is the most lethal brain tumor, and Wingless (Wg)-related integration site
(WNT) pathway activation in these tumors is associated with a poor prognosis. Clinically, the …

The regulatory dynamics of mitochondria comprises well orchestrated distribution and
mitochondrial turnover to maintain the mitochondrial circuitry and homeostasis inside the …