[HTML][HTML] Adipose tissue-derived extracellular fraction characterization: biological and clinical considerations in regenerative medicine

B Bellei, E Migliano, M Tedesco, S Caputo… - Stem Cell Research & …, 2018 - Springer
Background Adipose tissue-derived stem cells are considered to be a promising source in
the field of cell therapy and regenerative medicine. In addition to direct cell replacement …

[HTML][HTML] Targeting 2-oxoglutarate dehydrogenase for cancer treatment

LC Chang, SK Chiang, SE Chen… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Tricarboxylic acid (TCA) cycle, also called Krebs cycle or citric acid cycle, is an amphoteric
pathway, contributing to catabolic degradation and anaplerotic reactions to supply …

Antioxidant dihydrolipolic acid protects against in vitro aluminum‐induced toxicity

S Sanajou, A Yirün, G Demirel, DA Çakir… - Journal of Applied …, 2023 - Wiley Online Library
Dihydrolipoic acid (DHLA) is a natural antioxidant known for its ability to counteract metal
toxicity and oxidative stress. It has shown the potential to safeguard cells from harmful …

Growth factors and neuroglobin in astrocyte protection against neurodegeneration and oxidative stress

R Cabezas, E Baez-Jurado, O Hidalgo-Lanussa… - Molecular …, 2019 - Springer
Neurodegenerative diseases, such as Parkinson and Alzheimer, are among the main public
health issues in the world due to their effects on life quality and high mortality rates. Although …

Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review

NK Jha, WC Chen, S Kumar, R Dubey… - Open …, 2022 - royalsocietypublishing.org
Developmental signalling pathways such as Wnt/β-catenin, Notch and Sonic hedgehog play
a central role in nearly all the stages of neuronal development. The term 'embryonic'might …

Resveratrol protects SAMP8 brain under metabolic stress: focus on mitochondrial function and Wnt pathway

V Palomera-Avalos, C Griñán-Ferré… - Molecular …, 2017 - Springer
Metabolic stress induced by high-fat (HF) diet leads to cognitive dysfunction and aging, but
the physiological mechanisms are not fully understood. Senescence-accelerated prone …

[HTML][HTML] HR LC-MS/MS metabolomic profiling of Yucca aloifolia fruit and the potential neuroprotective effect on rotenone-induced Parkinson's disease in rats

DE Ali, SM Bassam, S Elatrebi, ES Habiba, EA Allam… - Plos one, 2023 - journals.plos.org
Yucca aloifolia L. fruit (Yucca or Spanish bayonet, family Asparagaceae) is recognized for its
purplish red color reflecting its anthocyanin content, which has a powerful antioxidant …

Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus

CB Lindsay, JM Zolezzi, DS Rivera, P Cisternas… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is a devastating neurodegenerative disorder in which superior
brain functions, such as memory and cognition, are impaired. Currently, no effective …

[HTML][HTML] Activation of Wnt signaling in cortical neurons enhances glucose utilization through glycolysis

P Cisternas, P Salazar, C Silva-Álvarez… - Journal of Biological …, 2016 - ASBMB
The Wnt signaling pathway is critical for a number of functions in the central nervous system,
including regulation of the synaptic cleft structure and neuroprotection against injury …

Intranasal wnt3a attenuates neuronal apoptosis through Frz1/PIWIL1a/FOXM1 pathway in MCAO rats

N Matei, J Camara, D McBride, R Camara… - Journal of …, 2018 - Soc Neuroscience
After ischemic stroke, apoptosis of neurons is a primary factor in determining outcome.
Wnt3a is a naturally occurring protein that has been shown to have protective effects in the …