Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases
M Zu, Y Ma, B Cannup, D Xie, Y Jung, J Zhang… - Advanced Drug Delivery …, 2021 - Elsevier
The incidence of inflammatory bowel disease (IBD) is rapidly rising throughout the world.
Although tremendous efforts have been made, limited therapeutics are available for IBD …
Although tremendous efforts have been made, limited therapeutics are available for IBD …
Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancer
M Zhang, X Li, Q Zhang, J Yang, G Liu - Frontiers in Immunology, 2023 - frontiersin.org
Colitis-associated colorectal cancer is the most serious complication of ulcerative colitis.
Long-term chronic inflammation increases the incidence of CAC in UC patients. Compared …
Long-term chronic inflammation increases the incidence of CAC in UC patients. Compared …
Orally deliverable sequence-targeted astaxanthin nanoparticles for colitis alleviation
Y Chen, W Su, S Tie, W Cui, X Yu, L Zhang, Z Hua… - Biomaterials, 2023 - Elsevier
Orally targeted strategy of anti-inflammatory agents has attracted tremendous attention for
reducing highly health-care costs and enhancing the intervention efficiency of ulcerative …
reducing highly health-care costs and enhancing the intervention efficiency of ulcerative …
Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization
MM Wu, QM Wang, BY Huang, CT Mai, CL Wang… - Pharmacological …, 2021 - Elsevier
Restoring immune balance by targeting macrophage polarization is a potentially valuable
therapeutic strategy for ulcerative colitis (UC). Dioscin is a steroidal saponin with potent anti …
therapeutic strategy for ulcerative colitis (UC). Dioscin is a steroidal saponin with potent anti …
Oral core–shell nanoparticles embedded in hydrogel microspheres for the efficient site-specific delivery of magnolol and enhanced antiulcerative colitis therapy
X Wang, H Gu, H Zhang, J Xian, J Li, C Fu… - … Applied Materials & …, 2021 - ACS Publications
Although magnolol (Mag), an anti-inflammatory natural compound, has been demonstrated
to play protective effects on ulcerative colitis (UC), its application as an alternative …
to play protective effects on ulcerative colitis (UC), its application as an alternative …
[HTML][HTML] Nano-in-micro alginate/chitosan hydrogel via electrospray technology for orally curcumin delivery to effectively alleviate ulcerative colitis
C Zhang, X Wang, M Xiao, J Ma, Y Qu, L Zou, J Zhang - Materials & Design, 2022 - Elsevier
Although nano-systems can promote the cellular internalization, polymeric nanoparticles
(NPs) are easily to be destroyed or eliminated in the gastrointestinal tract, which leads to …
(NPs) are easily to be destroyed or eliminated in the gastrointestinal tract, which leads to …
An engineered butyrate-derived polymer nanoplatform as a mucosa-healing enhancer potentiates the therapeutic effect of magnolol in inflammatory bowel disease
X Fan, Z Zhang, W Gao, Q Pan, K Luo, B He, Y Pu - ACS nano, 2023 - ACS Publications
Colonic epithelial damage and dysregulated immune response are crucial factors in the
progression and exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted …
progression and exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted …
[HTML][HTML] Macrophages in pancreatitis: Mechanisms and therapeutic potential
F Hu, N Lou, J Jiao, F Guo, H Xiang, D Shang - Biomedicine & …, 2020 - Elsevier
Macrophages play a crucial role in the pathogenesis of pancreatitis that is a common
gastrointestinal disease. Particularly, macrophages differentiate into different phenotypes …
gastrointestinal disease. Particularly, macrophages differentiate into different phenotypes …
Colon-targeted oral nanoparticles based on ROS-scavenging hydroxyethyl starch-curcumin conjugates for efficient inflammatory bowel disease therapy
C Xu, S Chen, C Chen, Y Ming, J Du, J Mu… - International Journal of …, 2022 - Elsevier
Co-delivery of anti-inflammatory drugs and reactive oxygen species (ROS) scavengers by
stimuli-responsive oral nanoparticles is deemed to be a favorable strategy for inflammatory …
stimuli-responsive oral nanoparticles is deemed to be a favorable strategy for inflammatory …
“Dual sensitive supramolecular curcumin nanoparticles” in “advanced yeast particles” mediate macrophage reprogramming, ROS scavenging and inflammation …
X Han, R Luo, S Qi, Y Wang, L Dai, W Nie, M Lin… - Journal of …, 2023 - Springer
Ulcerative colitis (UC) faces some barriers in oral therapy, such as how to safely deliver
drugs to the colon and accumulate in the colon lesions. Hence, we report an advanced yeast …
drugs to the colon and accumulate in the colon lesions. Hence, we report an advanced yeast …