Proteolytic activation of SARS‐CoV‐2 spike protein

M Takeda - Microbiology and immunology, 2022 - Wiley Online Library
Spike (S) protein cleavage is a crucial step in coronavirus infection. In this review, this
process is discussed, with particular focus on the novel coronavirus, severe acute …

SARS-CoV-2 infection: new molecular, phylogenetic, and pathogenetic insights. Efficacy of current vaccines and the potential risk of variants

JC Rotondo, F Martini, M Maritati, C Mazziotta… - Viruses, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered
coronavirus responsible for the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 …

[HTML][HTML] Coronavirus entry: how we arrived at SARS-CoV-2

GR Whittaker, S Daniel, JK Millet - Current opinion in virology, 2021 - Elsevier
Because of the COVID-19 pandemic, the novel coronavirus SARS-CoV-2 has risen to shape
scientific research during 2020, with its spike (S) protein being a predominant focus. The S …

SARS-CoV-2 fusion peptide has a greater membrane perturbating effect than SARS-CoV with highly specific dependence on Ca2+

AL Lai, JH Freed - Journal of Molecular Biology, 2021 - Elsevier
Coronaviruses are a major infectious disease threat, and include the zoonotic-origin human
pathogens SARS-CoV-2, SARS-CoV, and MERS-CoV (SARS-2, SARS-1, and MERS). Entry …

Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation

H Nguyen, HL Nguyen, PD Lan, NQ Thai… - Chemical Society …, 2023 - pubs.rsc.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

Membrane attachment and fusion of HIV-1, influenza A, and SARS-CoV-2: resolving the mechanisms with biophysical methods

G Negi, A Sharma, M Dey, G Dhanawat, N Parveen - Biophysical reviews, 2022 - Springer
Attachment to and fusion with cell membranes are two major steps in the replication cycle of
many human viruses. We focus on these steps for three enveloped viruses, ie, HIV-1, IAVs …

Binding of SARS-CoV-2 fusion peptide to host endosome and plasma membrane

SL Schaefer, H Jung, G Hummer - The journal of physical …, 2021 - ACS Publications
During infection the SARS-CoV-2 virus fuses its viral envelope with cellular membranes of
its human host. The viral spike (S) protein mediates both the initial contact with the host cell …

Inhibitors of L-type calcium channels show therapeutic potential for treating SARS-CoV-2 infections by preventing virus entry and spread

MR Straus, MK Bidon, T Tang, JA Jaimes… - ACS Infectious …, 2021 - ACS Publications
COVID-19 is caused by a novel coronavirus, the severe acute respiratory syndrome
coronavirus (CoV)-2 (SARS-CoV-2). The virus is responsible for an ongoing pandemic and …

COVID-19 and neurodegenerative diseases: prion-like spread and long-term consequences

N Baazaoui, K Iqbal - Journal of Alzheimer's Disease, 2022 - content.iospress.com
COVID-19 emerged as a global pandemic starting from Wuhan in China and spread at a
lightning speed to the rest of the world. One of the potential long-term outcomes that we …

The constellation of cholesterol-dependent processes associated with SARS-CoV-2 infection

FJ Barrantes - Progress in lipid research, 2022 - Elsevier
The role of cholesterol in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and other coronavirus-host cell interactions is currently being discussed in the context of two …