Substance use and common contributors to morbidity: A genetics perspective
Excessive substance use and substance use disorders (SUDs) are common, serious and
relapsing medical conditions. They frequently co-occur with other diseases that are leading …
relapsing medical conditions. They frequently co-occur with other diseases that are leading …
[HTML][HTML] A shared genetic signature for common chronic pain conditions and its impact on biopsychosocial traits
The multiple comorbidities & dimensions of chronic pain present a formidable challenge in
disentangling its aetiology. Here, we performed genome-wide association studies of 8 …
disentangling its aetiology. Here, we performed genome-wide association studies of 8 …
Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits
Despite the identification of a growing number of genetic risk loci for substance use traits
(SUTs), the impact of these loci on protein abundance and the potential utility of relevant …
(SUTs), the impact of these loci on protein abundance and the potential utility of relevant …
Genome‐wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression
Opioid use disorder (OUD) and mental disorders are often comorbid, with increased
morbidity and mortality. The causes underlying this relationship are poorly understood …
morbidity and mortality. The causes underlying this relationship are poorly understood …
[HTML][HTML] Identifying novel gene dysregulation associated with opioid overdose death: A meta-analysis of differential gene expression in human prefrontal cortex
Only recently have human postmortem brain studies of differential gene expression (DGE)
associated with opioid overdose death (OOD) been published; sample sizes from these …
associated with opioid overdose death (OOD) been published; sample sizes from these …
Accelerating opioid use disorders research by integrating multiple data modalities
SB Bianchi, AD Jeffery, DC Samuels, L Schirle… - Complex …, 2022 - karger.com
We are in the midst of a global opioid epidemic, which is driven by the misuse of both
prescription and illicit opioids. The metrics are overwhelming; eg, opioid overdose deaths …
prescription and illicit opioids. The metrics are overwhelming; eg, opioid overdose deaths …
Multi-omics analyses cannot identify true-positive novel associations from underpowered genome-wide association studies of four brain-related traits
Background The integration of multi-omics information (eg, epigenetics and transcriptomics)
can be useful for interpreting findings from genome-wide association studies (GWAS). It has …
can be useful for interpreting findings from genome-wide association studies (GWAS). It has …
Multi-ancestry meta-analysis of tobacco use disorders based on electronic health record data prioritizes novel candidate risk genes and reveals associations with …
S Toikumo, MV Jennings, B Pham, H Lee, TT Mallard… - medRxiv, 2023 - medrxiv.org
Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world.
Genetic factors influence smoking behaviors, and although strides have been made using …
Genetic factors influence smoking behaviors, and although strides have been made using …
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Excessive substance use and substance use disorders (SUDs) are common, serious and
relapsing medical conditions. They frequently co-occur with other diseases that are leading …
relapsing medical conditions. They frequently co-occur with other diseases that are leading …