The role and activity of SWI/SNF chromatin remodelers

T Bieluszewski, S Prakash, T Roulé… - Annual Review of Plant …, 2023 - annualreviews.org
SWITCH deficient SUCROSE NONFERMENTING (SWI/SNF) class chromatin remodeling
complexes (CRCs) use the energy derived from ATP hydrolysis to facilitate access of …

Shell protein composition specified by the lncRNA NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles

H Takakuwa, T Yamazaki, S Souquere, S Adachi… - Nature Cell …, 2023 - nature.com
Many membraneless organelles (MLOs) formed through phase separation play crucial roles
in various cellular processes. Although these MLOs co-exist in cells, how they maintain their …

Cohesin regulates alternative splicing

AK Singh, Q Chen, C Nguyen, D Meerzaman… - Science …, 2023 - science.org
Cohesin, a trimeric complex that establishes sister chromatid cohesion, has additional roles
in chromatin organization and transcription. We report that among those roles is the …

DNA methylation episignature and comparative epigenomic profiling of HNRNPU-related neurodevelopmental disorder

K Rooney, L van der Laan, S Trajkova… - Genetics in …, 2023 - Elsevier
Purpose HNRNPU haploinsufficiency is associated with developmental and epileptic
encephalopathy 54. This neurodevelopmental disorder is characterized by developmental …

Alpha‐synuclein promotes PRMT5‐mediated H4R3me2s histone methylation by interacting with the BAF complex

T Nakamura, N Sugeno, T Hasegawa… - The FEBS …, 2024 - Wiley Online Library
α‐Synuclein (αS) is a key molecule in the pathomechanism of Parkinson's disease. Most
studies on αS to date have focused on its function in the neuronal cytosol, but its action in …

[HTML][HTML] SWI/SNF-dependent genes are defined by their chromatin landscape

L Basurto-Cayuela, JA Guerrero-Martínez… - Cell Reports, 2024 - cell.com
SWI/SNF complexes are evolutionarily conserved, ATP-dependent chromatin remodeling
machines. Here, we characterize the features of SWI/SNF-dependent genes using BRM014 …

Extensive Alternative Splicing Patterns in Systemic Lupus Erythematosus Highlight Sexual Differences

D Kosmara, S Papanikolaou, C Nikolaou, G Bertsias - Cells, 2023 - mdpi.com
Substantial evidence highlights divergences in immune responses between men and
women. Women are more susceptible to autoimmunity, whereas men suffer from the more …

Minor Spliceosomal 65K/RNPC3 Interacts with ANKRD11 and Mediates HDAC3‐Regulated Histone Deacetylation and Transcription

CH Li, SB Liang, QW Huang, ZZ Zhou, Z Ding… - Advanced …, 2024 - Wiley Online Library
RNA splicing is crucial in the multilayer regulatory networks for gene expression, making
functional interactions with DNA‐and other RNA‐processing machineries in the nucleus …

Elucidation of the Landscape of Alternatively Spliced Genes and Features in the Dorsal Striatum of Aggressive/Aggression-Deprived Mice in the Model of Chronic …

V Babenko, O Redina, D Smagin, I Kovalenko… - Genes, 2023 - mdpi.com
Both aggressive and aggression-deprived (AD) individuals represent pathological cases
extensively studied in psychiatry and substance abuse disciplines. We employed the animal …

Multi-omic analysis of CIC's functional networks reveals novel interaction partners and a potential role in mitotic fidelity

Y Takemon, VG LeBlanc, J Song, SY Chan, SD Lee… - Cancers, 2023 - mdpi.com
Simple Summary Capicua (CIC) is a gene that is frequently mutated in several cancer types,
including stomach cancers and certain subtypes of brain tumours and sarcomas. CIC, the …