Abstract Background Coronaviruses (CoVs) primarily cause enzootic infections in birds and
mammals but, in the last few decades, have shown to be capable of infecting humans as …

Viroporins are virus encoded proteins that alter membrane permeability and can trigger
subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a …

Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically
relevant animal viruses. When these proteins oligomerize in host cell membranes, they form …

The HIV-1 accessory protein Vpu counteracts a host factor that restricts virion release from
infected cells. Here we show that the interferon-induced cellular protein BST-2/HM1 …

Antiviral restriction factors are host cellular proteins that constitute a first line of defense
blocking viral replication and propagation. In addition to interfering at critical steps of the …

The primary roles attributed to the human immunodeficiency virus type 1 (HIV-1) Vpu protein
are the degradation of the viral receptor CD4 and the enhancement of virion release. With …

Human immunodeficiency virus is undoubtedly the causative agent of AIDS. The
understanding of HIV-1 pathogenesis is essentiell to develop and maintain antiretroviral …

Fourteen ORFs have been identified in the severe acute respiratory syndrome-associated
coronavirus (SARS-CoV) genome. ORF 3a of SARS-CoV codes for a recently identified …

Severe Acute Respiratory Syndrome (SARS) is caused by a novel coronavirus (SARS-CoV).
Coronaviruses including SARS-CoV encode an envelope (E) protein, a small, hydrophobic …

Viroporins are a group of proteins that participate in several viral functions, including the
promotion of release of viral particles from cells. These proteins also affect cellular functions …