Isolation and characterization of lactoferrin peptides with stimulatory effect on osteoblast proliferation

F Fan, M Tu, M Liu, P Shi, Y Wang… - Journal of agricultural …, 2017 - ACS Publications
Lactoferrin is reported to be a potential food protein with osteogenic activity. However, the
activity of lactoferrin peptides is questionable. In the present study, we isolated and …

Antihypertensive mechanism of lactoferrin-derived peptides: angiotensin receptor blocking effect

R Fernandez-Musoles, M Castello-Ruiz… - Journal of agricultural …, 2014 - ACS Publications
Looking for antihypertensive mechanisms beyond ACE inhibition, we assessed whether
lactoferrin (LF)-derived peptides can act as receptor blockers to inhibit vasoconstriction …

Bioavailability of antihypertensive lactoferricin B-derived peptides: Transepithelial transport and resistance to intestinal and plasma peptidases

R Fernández-Musoles, JB Salom… - International Dairy …, 2013 - Elsevier
The transepithelial transport of the angiotensin I-converting enzyme (ACE)-inhibitory and
antihypertensive lactoferricin B (LfcinB)-derived hexapeptide LfcinB 20–25 (RRWQWR) and …

Antihypertensive effects of lactoferrin hydrolyzates: Inhibition of angiotensin-and endothelin-converting enzymes

R Fernández-Musoles, JB Salom, D Martínez-Maqueda… - Food chemistry, 2013 - Elsevier
The potential of bovine lactoferrin (LF) as a source of antihypertensive peptides acting on
the renin–angiotensin system (RAS) and the endothelin (ET) system as dual vasopeptidase …

Identification and availability of peptides from lactoferrin in the gastrointestinal tract of mice

F Fan, P Shi, H Chen, M Tu, Z Wang, W Lu, M Du - Food & function, 2019 - pubs.rsc.org
Lactoferrin is a protein with multifunctional bioactivities. However, limited studies have
reported the digestion behavior of lactoferrin in mice. In the present study, the metabolic fate …

Unraveling the mechanisms of action of lactoferrin-derived antihypertensive peptides: ACE inhibition and beyond

P Manzanares, JB Salom, A Garcia-Tejedor… - Food & function, 2015 - pubs.rsc.org
Hypertension is one of the most important causes of cardiovascular and renal morbidity and
mortality, and it represents a serious health problem in Western countries. Over the last few …

Use of an electrodialytic reactor for the simultaneous β-lactoglobulin enzymatic hydrolysis and fractionation of generated bioactive peptides

A Doyen, E Husson, L Bazinet - Food Chemistry, 2013 - Elsevier
The enzymatic hydrolysis of β-lactoglobulin and the fractionation of peptides were performed
in one step in an electrodialysis cell with ultrafiltration membranes stacked. After 240min of …

In vivo angiotensin I-converting enzyme inhibition by long-term intake of antihypertensive lactoferrin hydrolysate in spontaneously hypertensive rats

R Fernández-Musoles, P Manzanares… - Food Research …, 2013 - Elsevier
We evaluated the effect of the long-term intake of a bovine lactoferrin hydrolysate enriched
in low molecular weight peptides (LFH< 3 kDa) on the progression of hypertension in …

Complementation of UPLC-Q-TOF-MS and CESI-Q-TOF-MS on identification and determination of peptides from bovine lactoferrin

H Chen, P Shi, F Fan, M Tu, Z Xu, X Xu, M Du - Journal of Chromatography …, 2018 - Elsevier
Digested peptides of bovine lactoferrin as the functional hydrolysates were identified by the
Q-TOF tandem mass spectrometry (Q-TOF-MS) coupled with ultra performance liquid …

Current genetic engineering strategies for the production of antihypertensive ACEI peptides

C Gomes, D Ferreira, JPF Carvalho… - Biotechnology and …, 2020 - Wiley Online Library
Hypertension is a major and highly prevalent risk factor for various diseases. Among the
most frequently prescribed antihypertensive first‐line drugs are synthetic angiotensin I …