Intestinal macrophages in pathogenesis and treatment of gut leakage: current strategies and future perspectives

B Selvakumar, P Sekar… - Journal of Leukocyte …, 2024 - academic.oup.com
Macrophages play key roles in tissue homeostasis, defense, disease, and repair.
Macrophages are highly plastic and exhibit distinct functional phenotypes based on micro …

[HTML][HTML] Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease

M Biagioli, S Marchianò, C Di Giorgio, M Bordoni… - Biochemical …, 2023 - Elsevier
While patients with nonalcoholic fatty liver disease (NAFLD) are at increased risk to develop
clinically meaningful cardiovascular diseases (CVD), there are no approved drug designed …

TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response

M Zheng, Y Zhai, Y Yu, J Shen, S Chu, E Focaccia… - Cell Metabolism, 2024 - cell.com
The intestine constantly encounters and adapts to the external environment shaped by
diverse dietary nutrients. However, whether and how gut adaptability to dietary challenges is …

[HTML][HTML] Dietary long-chain fatty acids promote colitis by regulating palmitoylation of STAT3 through CD36-mediated endocytosis

Y Wei, J Li, J Li, C Liu, X Guo, Z Liu, L Zhang… - Cell Death & …, 2024 - nature.com
The Western diet, characterized by its high content of long-chain fatty acids (LCFAs), is
widely recognized as a significant triggering factor for inflammatory bowel disease (IBD) …

Comprehensive proteomic analysis of HCoV-OC43 virions and virus-modulated extracellular vesicles

N Joharinia, É Bonneil, N Grandvaux… - Journal of …, 2024 - Am Soc Microbiol
Viruses are obligate parasites that depend on the cellular machinery for their propagation.
Several viruses also incorporate cellular proteins that facilitate viral spread. Defining these …

Microbiota driven macrophage mediators in pathogenesis and treatment of gut leakage: current strategies and future perspectives

R Samsudin, B Selvakumar, P Sekar - Authorea Preprints, 2024 - techrxiv.org
Macrophages play key roles in tissue homeostasis, defense, disease and repair.
Macrophages are highly plastic and exhibit distinct functional phenotypes based on micro …