Tandem repeats (TRs) are prevalent throughout the genome, constituting at least 3% of the
genome, and often highly polymorphic. The high mutation rate of TRs, which can be orders …

Schizophrenia is routinely referred to as a neurodevelopmental disorder, but the role of
brain development in a disorder typically diagnosed during early adult life is enigmatic. The …

The polygenic architecture of schizophrenia implicates several molecular pathways involved
in synaptic function. However, it is unclear how polygenic risk funnels through these …

Alterations in fMRI-based brain functional network connectivity (FNC) are associated with
schizophrenia (SCZ) and the genetic risk or subthreshold clinical symptoms preceding the …

The connection and causality between cancer and neurodevelopmental disorders have
been puzzling. How can the same cellular pathways, proteins, and mutations lead to …

Cognitive dysfunctions are core-enduring symptoms of schizophrenia, with important sex-
related differences. Genetic variants of the DTBPN1 gene associated with reduced …

Abstract Objectives 22q11. 2 deletion is the most prominent risk factor for schizophrenia
(SZ). The aim of the present study was to identify unique transcriptome profile for 22q11. 2 …

The omnigenic model posits that genetic risk for traits with complex heritability involves
cumulative effects of peripheral genes on mechanistic" core genes," suggesting that in a …

The inaccessibility of neurons coming directly from patients has hindered our understanding
of mental illnesses at the cellular level. To overcome this obstacle, six different cellular …

Background miR-137 is a microRNA involved in brain development, regulating
neurogenesis and neuronal maturation. Genome-wide association studies have implicated …