Gliomas are a highly heterogeneous tumor, refractory to treatment and the most frequently
diagnosed primary brain tumor. Although the current WHO grading system (2016) …

ATP is required for mammalian cells to remain viable and to perform genetically
programmed functions. Maintenance of the ΔG′ ATP hydrolysis of− 56 kJ/mole is the …

Little progress has been made in the long-term management of glioblastoma multiforme
(GBM), considered among the most lethal of brain cancers. Cytotoxic chemotherapy …

Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain
cancers. Ultrastructural and biochemical evidence shows that GBM cells exhibit …

Glioblastoma (GBM) is an aggressive primary human brain tumour that has resisted effective
therapy for decades. Although glucose and glutamine are the major fuels that drive GBM …

Background Aberrant metabolism is recognized as a hallmark of cancer, a pillar necessary
for cellular proliferation. Regarding bioenergetics (ATP generation), most cancers display a …

De-regulated cellular energetics is an emerging hallmark of cancer with alterations to
glycolysis, oxidative phosphorylation, the pentose phosphate pathway, lipid oxidation and …

Few advances have been made in overall survival for glioblastoma multiforme (GBM) in
more than 40 years. Here, we report the case of a 38-year-old man who presented with …

The expression, cellular distribution, and subcellular sorting of the microtubule (MT)-
nucleating γ-tubulin small complex (γTuSC) proteins, GCP2 and GCP3, were studied in …

Purpose The prospective, randomized ERGO2 trial investigated the effect of calorie-
restricted ketogenic diet and intermittent fasting (KD-IF) on re-irradiation for recurrent brain …