Unifying mechanism for eye toxicity: electron transfer, reactive oxygen species, antioxidant benefits, cell signaling and cell membranes

P Kovacic, R Somanathan - Cell membranes and free radical …, 2008 - dergipark.org.tr
Eye toxicity comprises an important part in the category of insults to major organs. There is
considerable literature comprising industrial chemicals, atmospheric pollutants, metals …

Fluorescein angiography and adverse drug reactions revisited: the Lions Eye experience

ASL Kwan, C Barry, IL McAllister… - Clinical & experimental …, 2006 - Wiley Online Library
Background: The last major survey of adverse reactions to intravenous fluorescein
angiography was performed more than 20 years ago. There have been two recent fatalities …

Ophthalmic adverse drug reactions to systemic drugs: a systematic review

A Miguel, F Henriques, LF Azevedo… - … and drug safety, 2014 - Wiley Online Library
Purpose To perform a comprehensive and systematic review regarding ophthalmic adverse
drug reactions (ADRs) to systemic drugs to:(i) systematically summarize existing …

Safety evaluation of ocular drugs

MF Ramos, M Attar, JR Seals, KA Luhrs - A comprehensive guide to …, 2024 - Elsevier
The eye is particularly well suited for local drug delivery due to the size, location, and optical
clarity of tissues and is the mainstay for the treatment of ocular conditions. There are …

Statin-associated ocular disorders: the FDA and ADRAC data

V Mizranita, EH Pratisto - International journal of clinical pharmacy, 2015 - Springer
Background Statins are a class of medication indicated for atherosclerotic diseases and
dyslipidemia. Since their appearance, many adverse events have been associated with their …

Drugs and the retina

S Constable, M Pirmohamed - Expert Opinion on Drug Safety, 2004 - Taylor & Francis
The retina is relatively protected from systemic drug administration because of the blood–
retinal barrier, a highly selective mechanism adapted to providing a regulated homeostatic …

A current practice for predicting ocular toxicity of systemically delivered drugs

CJ Somps, N Greene, JA Render, MD Aleo… - … and ocular toxicology, 2009 - Taylor & Francis
The ability to predict ocular side effects of systemically delivered drugs is an important issue
for pharmaceutical companies. Although animal models involving standard clinical …

A behavioural operant discrimination model for assessment and pharmacological manipulation of visual function in rats

MA Carlsson, MDB Swedberg - Brain research, 2010 - Elsevier
A large number of commercially available drugs are known to cause visual side effects in
humans. Therefore, it would be advantageous to screen for alterations in visual function at a …

Methodologies for Microscopic Characterization of Ocular Toxicity

LBC Teixeira, JA Render - Ocular Pharmacology and Toxicology, 2014 - Springer
The eye is unique in being composed of different types of structures with various functions.
One needs to be aware of these unique aspects and changes due to spontaneous …

Pathology of the Eye

LBC Teixeira - Toxicologic Pathology for Non-Pathologists, 2019 - Springer
The eye is a complex organ composed of unique anatomical structures. Understanding the
functional anatomy and physiology of the eye is critical to understanding the pathology and …