Osteomyelitis remains one of the greatest risks in orthopaedic surgery. Although many
organisms are linked to skeletal infections, Staphylococcus aureus remains the most …

Objective: To review the spectrum of activity, efficacy, safety, and role in therapy of all
antibiotics and related biologics approved by the Food and Drug Administration (FDA) in the …

The emergence and global epidemic of antimicrobial resistance (AMR) poses a serious
threat to global public health in recent years. AMR genes are shared between bacterial …

Antimicrobial resistance (AMR) remains one of the top public health issues of global
concern. Among the most important strategies for AMR control there is the correct and …

Infective endocarditis (IE) is a life-threatening microbial infection of native and prosthetic
heart valves, endocardial surface, and/or indwelling cardiac device. Prevalence of IE is …

Due to the overuse of antibiotics, bacterial resistance has markedly increased to become a
global problem and a major threat to human health. Fortunately, in recent years, various new …

Mycobacterium tuberculosis (MTB) utilizes multiple mechanisms to obtain antibiotic
resistance during the treatment of infections. In addition, the biofilms, secreted by MTB, can …

The salification and prodrug approaches modulate the physicochemical properties and
absorption, distribution, metabolism, excretion, and toxicity parameters of drugs and lead …

Oritavancin displayed potent and stable activity (MIC90 range of 0.06 to 0.5 mg/L) over a 10-
year period (2010 to 2019) against Gram-positive pathogens that cause bloodstream …

Oritavancin (ORI) is a semisynthetic lipoglycopeptide approved as a single 1200 mg dose
intravenous infusion for the treatment of acute bacterial skin and skin structure infections …