The roles of matrix metalloproteinases and their inhibitors in human diseases

GA Cabral-Pacheco, I Garza-Veloz… - International journal of …, 2020 - mdpi.com
Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Vascular smooth muscle cells in atherosclerosis

GL Basatemur, HF Jørgensen, MCH Clarke… - Nature reviews …, 2019 - nature.com
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …

Sodium intake and hypertension

A Grillo, L Salvi, P Coruzzi, P Salvi, G Parati - Nutrients, 2019 - mdpi.com
The close relationship between hypertension and dietary sodium intake is widely
recognized and supported by several studies. A reduction in dietary sodium not only …

Molecular mechanisms of dermal aging and antiaging approaches

JW Shin, SH Kwon, JY Choi, JI Na, CH Huh… - International journal of …, 2019 - mdpi.com
The dermis is primarily composed of the extracellular matrix (ECM) and fibroblasts. During
the aging process, the dermis undergoes significant changes. Collagen, which is a major …

Matrix metalloproteinases, vascular remodeling, and vascular disease

X Wang, RA Khalil - Advances in pharmacology, 2018 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …

Matrix metalloproteinases as biomarkers of atherosclerotic plaque instability

W Olejarz, D Łacheta… - International journal of …, 2020 - mdpi.com
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases
responsible for tissue remodeling and degradation of extracellular matrix (ECM) proteins …

[HTML][HTML] Macrophage plasticity and atherosclerosis therapy

P Lin, HH Ji, YJ Li, SD Guo - Frontiers in molecular biosciences, 2021 - frontiersin.org
Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …

[HTML][HTML] Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications

A Harvey, AC Montezano, RA Lopes, F Rios… - Canadian Journal of …, 2016 - Elsevier
Aging is the primary risk factor underlying hypertension and incident cardiovascular disease.
With aging, the vasculature undergoes structural and functional changes characterized by …

Matrix metalloproteinase-9: Many shades of function in cardiovascular disease

A Yabluchanskiy, Y Ma, RP Iyer, ME Hall… - …, 2013 - journals.physiology.org
Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates
pathological remodeling processes that involve inflammation and fibrosis in cardiovascular …

The role of matrix metalloproteinase‐9 in atherosclerotic plaque instability

T Li, X Li, Y Feng, G Dong, Y Wang… - Mediators of …, 2020 - Wiley Online Library
Matrix metalloproteinase‐9 (MMP‐9) belongs to the MMP family and has been widely
investigated. Excessive MMP‐9 expression can enhance extracellular matrix degradation …