Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …

Metaplasia is the replacement of one differentiated somatic cell type with another
differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by …

Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and
treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas …

The mucosa of the body of the stomach (ie, the gastric corpus) uses 2 overlapping, depth-
dependent mechanisms to respond to injury. Superficial injury heals via surface cells with …

Despite the global prevalence of gastric disease, there are few adequate models in which to
study the fundus epithelium of the human stomach. We differentiated human pluripotent …

In 1900, Adami speculated that a sequence of context‐independent energetic and structural
changes governed the reversion of differentiated cells to a proliferative, regenerative state …

Background & Aims Chronic atrophic gastritis can lead to gastric metaplasia and increase
risk of gastric adenocarcinoma. Metaplasia is a precancerous lesion associated with an …

Tamoxifen, a selective estrogen receptor modulator, is widely used in research and clinically
in patients. We find that treatment of normal mice with a single≥ 3 mg/20 g body weight …

Advances in our understanding of stem cells in the gastrointestinal tract include the
identification of molecular markers of stem and early progenitor cells in the small intestine …

Subjected to countless daily injuries, the stomach still functions as a remarkably efficient
digestive organ and microbial filter. In this Review, we follow the lead of the earliest …