Pruritus or itch generated in the skin is one of the most widespread symptoms associated
with various dermatological and systemic (immunological) conditions. Although many details …

Introduction Psoriasis is a chronic, inflammatory, non-communicable skin disorder that
affects a patient's social and emotional well-being. It is characterized by hyperproliferation of …

Recent studies have illustrated that psoriatic lesions are innervated by dense sensory nerve
fibers. Psoriatic plaques appeared to improve after central or peripheral nerve injury …

TRPV4 is a calcium ion channel that is widely expressed in various cells. It is also involved
in physiological and pathological processes. However, the role of TRPV4 in psoriasis …

An increasing amount of evidence indicates the critical role of the cutaneous nervous system
in the initiation and maintenance of psoriatic skin lesions by neurogenic inflammation …

Background Smoking, obesity, and being below a healthy body weight are known to
increase all-cause mortality rates and are considered modifiable risk factors. The purpose of …

Psoriasis is a complex immune-mediated inflammatory disorder that generates enormous
interest within the scientific communities worldwide, with new therapeutic targets being …

Skin denervation has been shown to cause remission of psoriatic lesions in patients, which
can reappear if reinnervation occurs. This effect can be induced by the activation of dendritic …

Type I cannabinoid receptor (CB1R) has been reported to exhibit favorable anti-
inflammation and antipruritus effects against inflammation-based skin diseases, but the …

Intense mental stimulation and stress often directly induce or exacerbate psoriasis. On the
contrary, patients with nerve injury and nervous system dysfunction have psoriasis …